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Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis.
Tsien C, Davuluri G, Singh D, Allawy A, Ten Have GA, Thapaliya S, Schulze JM, Barnes D, McCullough AJ, Engelen MP, Deutz NE, Dasarathy S. Tsien C, et al. Among authors: davuluri g. Hepatology. 2015 Jun;61(6):2018-29. doi: 10.1002/hep.27717. Epub 2015 Feb 27. Hepatology. 2015. PMID: 25613922 Free PMC article. Clinical Trial.
Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease.
Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Davuluri G, et al. Hepatology. 2021 May;73(5):1892-1908. doi: 10.1002/hep.31524. Epub 2021 Apr 20. Hepatology. 2021. PMID: 32799332 Free PMC article.
Hyperammonemia results in reduced muscle function independent of muscle mass.
McDaniel J, Davuluri G, Hill EA, Moyer M, Runkana A, Prayson R, van Lunteren E, Dasarathy S. McDaniel J, et al. Among authors: davuluri g. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 1;310(3):G163-70. doi: 10.1152/ajpgi.00322.2015. Epub 2015 Dec 3. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 26635319 Free PMC article.
Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations.
Kant S, Davuluri G, Alchirazi KA, Welch N, Heit C, Kumar A, Gangadhariah M, Kim A, McMullen MR, Willard B, Luse DS, Nagy LE, Vasiliou V, Marini AM, Weiner ID, Dasarathy S. Kant S, et al. Among authors: davuluri g. J Biol Chem. 2019 May 3;294(18):7231-7244. doi: 10.1074/jbc.RA118.005411. Epub 2019 Mar 14. J Biol Chem. 2019. PMID: 30872403 Free PMC article.
Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy.
Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S. Kumar A, et al. Among authors: davuluri g. Free Radic Biol Med. 2019 Dec;145:284-299. doi: 10.1016/j.freeradbiomed.2019.09.031. Epub 2019 Sep 28. Free Radic Biol Med. 2019. PMID: 31574345 Free PMC article.
Integrated multiomics analysis identifies molecular landscape perturbations during hyperammonemia in skeletal muscle and myotubes.
Welch N, Singh SS, Kumar A, Dhruba SR, Mishra S, Sekar J, Bellar A, Attaway AH, Chelluboyina A, Willard BB, Li L, Huo Z, Karnik SS, Esser K, Longworth MS, Shah YM, Davuluri G, Pal R, Dasarathy S. Welch N, et al. Among authors: davuluri g. J Biol Chem. 2021 Sep;297(3):101023. doi: 10.1016/j.jbc.2021.101023. Epub 2021 Jul 31. J Biol Chem. 2021. PMID: 34343564 Free PMC article.
51 results