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Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome.
Meuwissen ME, Schot R, Buta S, Oudesluijs G, Tinschert S, Speer SD, Li Z, van Unen L, Heijsman D, Goldmann T, Lequin MH, Kros JM, Stam W, Hermann M, Willemsen R, Brouwer RW, Van IJcken WF, Martin-Fernandez M, de Coo I, Dudink J, de Vries FA, Bertoli Avella A, Prinz M, Crow YJ, Verheijen FW, Pellegrini S, Bogunovic D, Mancini GM. Meuwissen ME, et al. Among authors: prinz m. J Exp Med. 2016 Jun 27;213(7):1163-74. doi: 10.1084/jem.20151529. Epub 2016 Jun 20. J Exp Med. 2016. PMID: 27325888 Free PMC article. Clinical Trial.
Role of microglia in CNS autoimmunity.
Goldmann T, Prinz M. Goldmann T, et al. Among authors: prinz m. Clin Dev Immunol. 2013;2013:208093. doi: 10.1155/2013/208093. Epub 2013 Jun 12. Clin Dev Immunol. 2013. PMID: 23840238 Free PMC article. Review.
Microglia fuel the learning brain.
Blank T, Goldmann T, Prinz M. Blank T, et al. Among authors: prinz m. Trends Immunol. 2014 Apr;35(4):139-40. doi: 10.1016/j.it.2014.02.005. Epub 2014 Mar 11. Trends Immunol. 2014. PMID: 24636251 Review.
Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.
Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP. Ketscher L, et al. Among authors: prinz m. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605921 Free PMC article.
USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M. Goldmann T, et al. Among authors: prinz m. EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20. EMBO J. 2015. PMID: 25896511 Free PMC article.
Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson's Disease-like Dementia.
Ejlerskov P, Hultberg JG, Wang J, Carlsson R, Ambjørn M, Kuss M, Liu Y, Porcu G, Kolkova K, Friis Rundsten C, Ruscher K, Pakkenberg B, Goldmann T, Loreth D, Prinz M, Rubinsztein DC, Issazadeh-Navikas S. Ejlerskov P, et al. Among authors: prinz m. Cell. 2015 Oct 8;163(2):324-39. doi: 10.1016/j.cell.2015.08.069. Cell. 2015. PMID: 26451483 Free PMC article.
703 results