Lu R - Search Results

1

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.

Lu R, Wang P, Parton T, Zhou Y, Chrysovergis K, Rockowitz S, Chen WY, Abdel-Wahab O, Wade PA, Zheng D, Wang GG. Lu R, et al. Cancer Cell. 2016 Jul 11;30(1):92-107. doi: 10.1016/j.ccell.2016.05.008. Epub 2016 Jun 23. Cancer Cell. 2016. PMID: 27344947 Free PMC article.

2

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.

Cai L, Rothbart SB, Lu R, Xu B, Chen WY, Tripathy A, Rockowitz S, Zheng D, Patel DJ, Allis CD, Strahl BD, Song J, Wang GG. Cai L, et al. Among authors: lu r. Mol Cell. 2013 Feb 7;49(3):571-82. doi: 10.1016/j.molcel.2012.11.026. Epub 2012 Dec 27. Mol Cell. 2013. PMID: 23273982 Free PMC article.

3

Tudor: a versatile family of histone methylation 'readers'.

Lu R, Wang GG. Lu R, et al. Trends Biochem Sci. 2013 Nov;38(11):546-55. doi: 10.1016/j.tibs.2013.08.002. Epub 2013 Sep 10. Trends Biochem Sci. 2013. PMID: 24035451 Free PMC article. Review.

4

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming.

Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin C, Fu JD, Wang GG, Liu J, Qian L. Zhou Y, et al. Among authors: lu r. Cell Stem Cell. 2016 Mar 3;18(3):382-95. doi: 10.1016/j.stem.2016.02.003. Cell Stem Cell. 2016. PMID: 26942853 Free PMC article.

5

Gene enhancer deregulation and epigenetic vulnerability.

Lu R, Wang GG. Lu R, et al. Oncoscience. 2016 Dec 21;3(11-12):299-301. doi: 10.18632/oncoscience.334. eCollection 2016. Oncoscience. 2016. PMID: 28105447 Free PMC article. No abstract available.

6

Pharmacologic Targeting of Chromatin Modulators As Therapeutics of Acute Myeloid Leukemia.

Lu R, Wang GG. Lu R, et al. Front Oncol. 2017 Oct 12;7:241. doi: 10.3389/fonc.2017.00241. eCollection 2017. Front Oncol. 2017. PMID: 29075615 Free PMC article. Review.

7

Structural basis for DNMT3A-mediated de novo DNA methylation.

Zhang ZM, Lu R, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG, Song J. Zhang ZM, et al. Among authors: lu r. Nature. 2018 Feb 15;554(7692):387-391. doi: 10.1038/nature25477. Epub 2018 Feb 7. Nature. 2018. PMID: 29414941 Free PMC article.

8

The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem Cells.

Xu B, Cai L, Butler JM, Chen D, Lu X, Allison DF, Lu R, Rafii S, Parker JS, Zheng D, Wang GG. Xu B, et al. Among authors: lu x, lu r. Stem Cell Reports. 2018 Mar 13;10(3):675-683. doi: 10.1016/j.stemcr.2018.01.020. Epub 2018 Feb 15. Stem Cell Reports. 2018. PMID: 29456179 Free PMC article.

9

ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer.

Cai L, Tsai YH, Wang P, Wang J, Li D, Fan H, Zhao Y, Bareja R, Lu R, Wilson EM, Sboner A, Whang YE, Zheng D, Parker JS, Earp HS, Wang GG. Cai L, et al. Among authors: lu r. Mol Cell. 2018 Oct 18;72(2):341-354.e6. doi: 10.1016/j.molcel.2018.08.029. Epub 2018 Sep 27. Mol Cell. 2018. PMID: 30270106 Free PMC article.

10

A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3A^R882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis.

Lu R, Wang J, Ren Z, Yin J, Wang Y, Cai L, Wang GG. Lu R, et al. Cancer Res. 2019 Jul 15;79(14):3583-3594. doi: 10.1158/0008-5472.CAN-18-3275. Epub 2019 Jun 4. Cancer Res. 2019. PMID: 31164355 Free PMC article.

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