High-mobility group box 1 inhibits HCO3- absorption in the medullary thick ascending limb through RAGE-Rho-ROCK-mediated inhibition of basolateral Na+/H+ exchange.
Watts BA 3rd, George T, Badalamenti A, Good DW.
Watts BA 3rd, et al. Among authors: good dw.
Am J Physiol Renal Physiol. 2016 Sep 1;311(3):F600-13. doi: 10.1152/ajprenal.00185.2016. Epub 2016 Jun 29.
Am J Physiol Renal Physiol. 2016.
PMID: 27358052
Free PMC article.
Recently, we demonstrated that HMGB1 inhibits HCO3 (-) absorption in perfused rat medullary thick ascending limbs (MTAL) through a basolateral receptor for advanced glycation end products (RAGE)-dependent pathway that is additive to Toll-like receptor 4 (TLR4)-ERK-mediated inhibi …
Recently, we demonstrated that HMGB1 inhibits HCO3 (-) absorption in perfused rat medullary thick ascending limbs (MTAL) through a basolater …