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108 results

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Page 1
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment.
Zeng Z, Shi YX, Tsao T, Qiu Y, Kornblau SM, Baggerly KA, Liu W, Jessen K, Liu Y, Kantarjian H, Rommel C, Fruman DA, Andreeff M, Konopleva M. Zeng Z, et al. Among authors: rommel c. Blood. 2012 Sep 27;120(13):2679-89. doi: 10.1182/blood-2011-11-393934. Epub 2012 Jul 23. Blood. 2012. PMID: 22826565 Free PMC article.
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.
Janes MR, Limon JJ, So L, Chen J, Lim RJ, Chavez MA, Vu C, Lilly MB, Mallya S, Ong ST, Konopleva M, Martin MB, Ren P, Liu Y, Rommel C, Fruman DA. Janes MR, et al. Among authors: rommel c. Nat Med. 2010 Feb;16(2):205-13. doi: 10.1038/nm.2091. Epub 2010 Jan 13. Nat Med. 2010. PMID: 20072130 Free PMC article.
Selective inhibition of phosphoinositide 3-kinase p110α preserves lymphocyte function.
So L, Yea SS, Oak JS, Lu M, Manmadhan A, Ke QH, Janes MR, Kessler LV, Kucharski JM, Li LS, Martin MB, Ren P, Jessen KA, Liu Y, Rommel C, Fruman DA. So L, et al. Among authors: rommel c. J Biol Chem. 2013 Feb 22;288(8):5718-31. doi: 10.1074/jbc.M112.379446. Epub 2012 Dec 28. J Biol Chem. 2013. PMID: 23275335 Free PMC article.
PI3K and cancer: lessons, challenges and opportunities.
Fruman DA, Rommel C. Fruman DA, et al. Among authors: rommel c. Nat Rev Drug Discov. 2014 Feb;13(2):140-56. doi: 10.1038/nrd4204. Nat Rev Drug Discov. 2014. PMID: 24481312 Free PMC article. Review.
The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Hsieh AC, Liu Y, Edlind MP, Ingolia NT, Janes MR, Sher A, Shi EY, Stumpf CR, Christensen C, Bonham MJ, Wang S, Ren P, Martin M, Jessen K, Feldman ME, Weissman JS, Shokat KM, Rommel C, Ruggero D. Hsieh AC, et al. Among authors: rommel c. Nature. 2012 Feb 22;485(7396):55-61. doi: 10.1038/nature10912. Nature. 2012. PMID: 22367541 Free PMC article.
Dual mTORC1/2 and HER2 blockade results in antitumor activity in preclinical models of breast cancer resistant to anti-HER2 therapy.
García-García C, Ibrahim YH, Serra V, Calvo MT, Guzmán M, Grueso J, Aura C, Pérez J, Jessen K, Liu Y, Rommel C, Tabernero J, Baselga J, Scaltriti M. García-García C, et al. Among authors: rommel c. Clin Cancer Res. 2012 May 1;18(9):2603-12. doi: 10.1158/1078-0432.CCR-11-2750. Epub 2012 Mar 8. Clin Cancer Res. 2012. PMID: 22407832
108 results