Costa T - Search Results

1

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation.

Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, Kobilka BK, Costa T, Lefkowitz RJ. Staus DP, et al. Among authors: costa t. Nature. 2016 Jul 21;535(7612):448-52. doi: 10.1038/nature18636. Epub 2016 Jul 13. Nature. 2016. PMID: 27409812 Free PMC article.

2

Unique Positive Cooperativity Between the β-Arrestin-Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor.

Pani B, Ahn S, Rambarat PK, Vege S, Kahsai AW, Liu A, Valan BN, Staus DP, Costa T, Lefkowitz RJ. Pani B, et al. Among authors: costa t. Mol Pharmacol. 2021 Nov;100(5):513-525. doi: 10.1124/molpharm.121.000363. Epub 2021 Sep 27. Mol Pharmacol. 2021. PMID: 34580163 Free PMC article.

3

Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR).

Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Strachan RT, et al. Among authors: costa t. J Biol Chem. 2014 May 16;289(20):14211-24. doi: 10.1074/jbc.M114.548131. Epub 2014 Mar 25. J Biol Chem. 2014. PMID: 24668815 Free PMC article.

4

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

Samama P, Pei G, Costa T, Cotecchia S, Lefkowitz RJ. Samama P, et al. Among authors: costa t. Mol Pharmacol. 1994 Mar;45(3):390-4. Mol Pharmacol. 1994. PMID: 7908404

5

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Samama P, Cotecchia S, Costa T, Lefkowitz RJ. Samama P, et al. Among authors: costa t. J Biol Chem. 1993 Mar 5;268(7):4625-36. J Biol Chem. 1993. PMID: 8095262 Free article.

6

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.

Lefkowitz RJ, Cotecchia S, Samama P, Costa T. Lefkowitz RJ, et al. Among authors: costa t. Trends Pharmacol Sci. 1993 Aug;14(8):303-7. doi: 10.1016/0165-6147(93)90048-O. Trends Pharmacol Sci. 1993. PMID: 8249148 Review.

7

Where have all the active receptor states gone?

Onaran HO, Costa T. Onaran HO, et al. Among authors: costa t. Nat Chem Biol. 2012 Jul 18;8(8):674-7. doi: 10.1038/nchembio.1024. Nat Chem Biol. 2012. PMID: 22810762

8

Allosteric coupling and conformational fluctuations in proteins.

Onaran HO, Costa T. Onaran HO, et al. Among authors: costa t. Curr Protein Pept Sci. 2009 Apr;10(2):110-5. doi: 10.2174/138920309787847644. Curr Protein Pept Sci. 2009. PMID: 19355978

9

Ligands raise the constraint that limits constitutive activation in G protein-coupled opioid receptors.

Vezzi V, Onaran HO, Molinari P, Guerrini R, Balboni G, Calò G, Costa T. Vezzi V, et al. Among authors: costa t. J Biol Chem. 2013 Aug 16;288(33):23964-78. doi: 10.1074/jbc.M113.474452. Epub 2013 Jul 8. J Biol Chem. 2013. PMID: 23836900 Free PMC article.

10

Different structural requirements for the constitutive and the agonist-induced activities of the beta2-adrenergic receptor.

Ambrosio C, Molinari P, Fanelli F, Chuman Y, Sbraccia M, Ugur O, Costa T. Ambrosio C, et al. Among authors: costa t. J Biol Chem. 2005 Jun 24;280(25):23464-74. doi: 10.1074/jbc.M502901200. Epub 2005 Apr 21. J Biol Chem. 2005. PMID: 15845544 Free article.

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