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A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.
Aflaki E, Borger DK, Moaven N, Stubblefield BK, Rogers SA, Patnaik S, Schoenen FJ, Westbroek W, Zheng W, Sullivan P, Fujiwara H, Sidhu R, Khaliq ZM, Lopez GJ, Goldstein DS, Ory DS, Marugan J, Sidransky E. Aflaki E, et al. Among authors: sullivan p. J Neurosci. 2016 Jul 13;36(28):7441-52. doi: 10.1523/JNEUROSCI.0636-16.2016. J Neurosci. 2016. PMID: 27413154 Free PMC article.
Conditional expression of Parkinson's disease-related mutant α-synuclein in the midbrain dopaminergic neurons causes progressive neurodegeneration and degradation of transcription factor nuclear receptor related 1.
Lin X, Parisiadou L, Sgobio C, Liu G, Yu J, Sun L, Shim H, Gu XL, Luo J, Long CX, Ding J, Mateo Y, Sullivan PH, Wu LG, Goldstein DS, Lovinger D, Cai H. Lin X, et al. J Neurosci. 2012 Jul 4;32(27):9248-64. doi: 10.1523/JNEUROSCI.1731-12.2012. J Neurosci. 2012. PMID: 22764233 Free PMC article.
The serotonin aldehyde, 5-HIAL, oligomerizes alpha-synuclein.
Jinsmaa Y, Cooney A, Sullivan P, Sharabi Y, Goldstein DS. Jinsmaa Y, et al. Among authors: sullivan p. Neurosci Lett. 2015 Mar 17;590:134-7. doi: 10.1016/j.neulet.2015.01.064. Epub 2015 Jan 28. Neurosci Lett. 2015. PMID: 25637699 Free PMC article.
Catechols in post-mortem brain of patients with Parkinson disease.
Goldstein DS, Sullivan P, Holmes C, Kopin IJ, Basile MJ, Mash DC. Goldstein DS, et al. Among authors: sullivan p. Eur J Neurol. 2011 May;18(5):703-10. doi: 10.1111/j.1468-1331.2010.03246.x. Epub 2010 Nov 12. Eur J Neurol. 2011. PMID: 21073636 Free PMC article.
3,126 results