Skovbakke SL - Search Results

1

The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2 Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase.

Holdfeldt A, Skovbakke SL, Winther M, Gabl M, Nielsen C, Perez-Gassol I, Larsen CJ, Wang JM, Karlsson A, Dahlgren C, Forsman H, Franzyk H. Holdfeldt A, et al. Among authors: skovbakke sl. J Biol Chem. 2016 Sep 16;291(38):19888-99. doi: 10.1074/jbc.M116.736850. Epub 2016 Jul 15. J Biol Chem. 2016. PMID: 27422818 Free PMC article.

2

Lipidated α-peptide/β-peptoid hybrids with potent anti-inflammatory activity.

Skovbakke SL, Larsen CJ, Heegaard PM, Moesby L, Franzyk H. Skovbakke SL, et al. J Med Chem. 2015 Jan 22;58(2):801-13. doi: 10.1021/jm501341h. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25489798

3

A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.

Gabl M, Winther M, Skovbakke SL, Bylund J, Dahlgren C, Forsman H. Gabl M, et al. Among authors: skovbakke sl. PLoS One. 2014 Oct 10;9(10):e109516. doi: 10.1371/journal.pone.0109516. eCollection 2014. PLoS One. 2014. PMID: 25303226 Free PMC article.

4

Structural changes of the ligand and of the receptor alters the receptor preference for neutrophil activating peptides starting with a formylmethionyl group.

Forsman H, Winther M, Gabl M, Skovbakke SL, Boulay F, Rabiet MJ, Dahlgren C. Forsman H, et al. Among authors: skovbakke sl. Biochim Biophys Acta. 2015 Jan;1853(1):192-200. doi: 10.1016/j.bbamcr.2014.10.021. Epub 2014 Oct 30. Biochim Biophys Acta. 2015. PMID: 25447672 Free article.

5

The proteolytically stable peptidomimetic Pam-(Lys-βNSpe)6-NH2 selectively inhibits human neutrophil activation via formyl peptide receptor 2.

Skovbakke SL, Heegaard PM, Larsen CJ, Franzyk H, Forsman H, Dahlgren C. Skovbakke SL, et al. Biochem Pharmacol. 2015 Jan 15;93(2):182-95. doi: 10.1016/j.bcp.2014.11.004. Epub 2014 Nov 14. Biochem Pharmacol. 2015. PMID: 25462815

6

The peptidomimetic Lau-(Lys-βNSpe)₆-NH₂ antagonizes formyl peptide receptor 2 expressed in mouse neutrophils.

Skovbakke SL, Winther M, Gabl M, Holdfeldt A, Linden S, Wang JM, Dahlgren C, Franzyk H, Forsman H. Skovbakke SL, et al. Biochem Pharmacol. 2016 Nov 1;119:56-65. doi: 10.1016/j.bcp.2016.09.004. Epub 2016 Sep 8. Biochem Pharmacol. 2016. PMID: 27614010

7

Combining Elements from Two Antagonists of Formyl Peptide Receptor 2 Generates More Potent Peptidomimetic Antagonists.

Skovbakke SL, Holdfeldt A, Nielsen C, Hansen AM, Perez-Gassol I, Dahlgren C, Forsman H, Franzyk H. Skovbakke SL, et al. J Med Chem. 2017 Aug 24;60(16):6991-6997. doi: 10.1021/acs.jmedchem.7b00489. Epub 2017 Aug 10. J Med Chem. 2017. PMID: 28700225

8

The Role of Formyl Peptide Receptors for Immunomodulatory Activities of Antimicrobial Peptides and Peptidomimetics.

Skovbakke SL, Holdfeldt A, Forsman H, Bylund J, Franzyk H. Skovbakke SL, et al. Curr Pharm Des. 2018;24(10):1100-1120. doi: 10.2174/1381612824666180403123233. Curr Pharm Des. 2018. PMID: 29611477 Review.

9

In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)₆-NH₂ and Lau-(Lys-βNspe)₆-NH₂ Against PMA-Induced Acute Inflammation.

Wu BC, Skovbakke SL, Masoudi H, Hancock REW, Franzyk H. Wu BC, et al. Among authors: skovbakke sl. Front Immunol. 2020 Aug 28;11:2102. doi: 10.3389/fimmu.2020.02102. eCollection 2020. Front Immunol. 2020. PMID: 32983167 Free PMC article.

10

Anti-inflammatory Properties of Antimicrobial Peptides and Peptidomimetics: LPS and LTA Neutralization.

Skovbakke SL, Franzyk H. Skovbakke SL, et al. Methods Mol Biol. 2017;1548:369-386. doi: 10.1007/978-1-4939-6737-7_27. Methods Mol Biol. 2017. PMID: 28013519

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