Kapilashrami K - Search Results

1

N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis.

Warrier T, Kapilashrami K, Argyrou A, Ioerger TR, Little D, Murphy KC, Nandakumar M, Park S, Gold B, Mi J, Zhang T, Meiler E, Rees M, Somersan-Karakaya S, Porras-De Francisco E, Martinez-Hoyos M, Burns-Huang K, Roberts J, Ling Y, Rhee KY, Mendoza-Losana A, Luo M, Nathan CF. Warrier T, et al. Among authors: kapilashrami k. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4523-30. doi: 10.1073/pnas.1606590113. Epub 2016 Jul 18. Proc Natl Acad Sci U S A. 2016. PMID: 27432954 Free PMC article.

2

Synthesis and Assays of Inhibitors of Methyltransferases.

Cai XC, Kapilashrami K, Luo M. Cai XC, et al. Among authors: kapilashrami k. Methods Enzymol. 2016;574:245-308. doi: 10.1016/bs.mie.2016.01.009. Epub 2016 Mar 28. Methods Enzymol. 2016. PMID: 27423865

3

Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.

Linscott JA, Kapilashrami K, Wang Z, Senevirathne C, Bothwell IR, Blum G, Luo M. Linscott JA, et al. Among authors: kapilashrami k. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8369-E8378. doi: 10.1073/pnas.1609032114. Epub 2016 Dec 9. Proc Natl Acad Sci U S A. 2016. PMID: 27940912 Free PMC article.

4

Substrate-Differentiated Transition States of SET7/9-Catalyzed Lysine Methylation.

Chen S, Kapilashrami K, Senevirathne C, Wang Z, Wang J, Linscott JA, Luo M. Chen S, et al. Among authors: kapilashrami k. J Am Chem Soc. 2019 May 22;141(20):8064-8067. doi: 10.1021/jacs.9b02553. Epub 2019 May 14. J Am Chem Soc. 2019. PMID: 31034218 Free PMC article.

5

Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents.

Aldawsari FS, Aguayo-Ortiz R, Kapilashrami K, Yoo J, Luo M, Medina-Franco JL, Velázquez-Martínez CA. Aldawsari FS, et al. Among authors: kapilashrami k. J Enzyme Inhib Med Chem. 2016 Oct;31(5):695-703. doi: 10.3109/14756366.2015.1058256. Epub 2015 Jun 29. J Enzyme Inhib Med Chem. 2016. PMID: 26118420 Free PMC article.

6

Structural basis for the recognition of mycolic acid precursors by KasA, a condensing enzyme and drug target from Mycobacterium tuberculosis.

Schiebel J, Kapilashrami K, Fekete A, Bommineni GR, Schaefer CM, Mueller MJ, Tonge PJ, Kisker C. Schiebel J, et al. Among authors: kapilashrami k. J Biol Chem. 2013 Nov 22;288(47):34190-34204. doi: 10.1074/jbc.M113.511436. Epub 2013 Oct 9. J Biol Chem. 2013. PMID: 24108128 Free PMC article.

7

Thiolactomycin-based β-ketoacyl-AcpM synthase A (KasA) inhibitors: fragment-based inhibitor discovery using transient one-dimensional nuclear overhauser effect NMR spectroscopy.

Kapilashrami K, Bommineni GR, Machutta CA, Kim P, Lai CT, Simmerling C, Picart F, Tonge PJ. Kapilashrami K, et al. J Biol Chem. 2013 Mar 1;288(9):6045-52. doi: 10.1074/jbc.M112.414516. Epub 2013 Jan 10. J Biol Chem. 2013. PMID: 23306195 Free PMC article.

8

Inhibition of ALK2 with bicyclic pyridyllactams.

Witten MR, Wu L, Lai CT, Kapilashrami K, Pusey M, Gallagher K, Chen Y, Yao W. Witten MR, et al. Among authors: kapilashrami k. Bioorg Med Chem Lett. 2022 Jan 1;55:128452. doi: 10.1016/j.bmcl.2021.128452. Epub 2021 Nov 13. Bioorg Med Chem Lett. 2022. PMID: 34780900

9

Thiolactomycin-Based Inhibitors of Bacterial β-Ketoacyl-ACP Synthases with in Vivo Activity.

Bommineni GR, Kapilashrami K, Cummings JE, Lu Y, Knudson SE, Gu C, Walker SG, Slayden RA, Tonge PJ. Bommineni GR, et al. Among authors: kapilashrami k. J Med Chem. 2016 Jun 9;59(11):5377-90. doi: 10.1021/acs.jmedchem.6b00236. Epub 2016 May 24. J Med Chem. 2016. PMID: 27187871 Free PMC article.

10

Slow onset inhibition of bacterial beta-ketoacyl-acyl carrier protein synthases by thiolactomycin.

Machutta CA, Bommineni GR, Luckner SR, Kapilashrami K, Ruzsicska B, Simmerling C, Kisker C, Tonge PJ. Machutta CA, et al. Among authors: kapilashrami k. J Biol Chem. 2010 Feb 26;285(9):6161-9. doi: 10.1074/jbc.M109.077909. Epub 2009 Dec 16. J Biol Chem. 2010. PMID: 20018879 Free PMC article.

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