Hirsch AK - Search Results

1

Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.

Masini T, Birkaya B, van Dijk S, Mondal M, Hekelaar J, Jäger M, Terwisscha van Scheltinga AC, Patel MS, Hirsch AK, Moman E. Masini T, et al. Among authors: hirsch ak. J Enzyme Inhib Med Chem. 2016;31(sup4):170-175. doi: 10.1080/14756366.2016.1201812. Epub 2016 Jul 19. J Enzyme Inhib Med Chem. 2016. PMID: 27435185 Free PMC article.

2

Druggability of the enzymes of the non-mevalonate-pathway.

Masini T, Kroezen BS, Hirsch AK. Masini T, et al. Among authors: hirsch ak. Drug Discov Today. 2013 Dec;18(23-24):1256-62. doi: 10.1016/j.drudis.2013.07.003. Epub 2013 Jul 13. Drug Discov Today. 2013. PMID: 23856326 Review.

3

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch AK. Mondal M, et al. Among authors: hirsch ak. Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3259-63. doi: 10.1002/anie.201309682. Epub 2014 Feb 14. Angew Chem Int Ed Engl. 2014. PMID: 24532096

4

Development of inhibitors of the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway enzymes as potential anti-infective agents.

Masini T, Hirsch AK. Masini T, et al. Among authors: hirsch ak. J Med Chem. 2014 Dec 11;57(23):9740-63. doi: 10.1021/jm5010978. Epub 2014 Sep 25. J Med Chem. 2014. PMID: 25210872 Review.

5

Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets.

Mondal M, Hirsch AK. Mondal M, et al. Among authors: hirsch ak. Chem Soc Rev. 2015 Apr 21;44(8):2455-88. doi: 10.1039/c4cs00493k. Chem Soc Rev. 2015. PMID: 25706945 Review.

6

Fighting malaria: structure-guided discovery of nonpeptidomimetic plasmepsin inhibitors.

Huizing AP, Mondal M, Hirsch AK. Huizing AP, et al. Among authors: hirsch ak. J Med Chem. 2015 Jul 9;58(13):5151-63. doi: 10.1021/jm5014133. Epub 2015 Mar 17. J Med Chem. 2015. PMID: 25719272

7

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.

Hartman AM, Mondal M, Radeva N, Klebe G, Hirsch AK. Hartman AM, et al. Among authors: hirsch ak. Int J Mol Sci. 2015 Aug 14;16(8):19184-94. doi: 10.3390/ijms160819184. Int J Mol Sci. 2015. PMID: 26287174 Free PMC article.

8

Validation of a homology model of Mycobacterium tuberculosis DXS: rationalization of observed activities of thiamine derivatives as potent inhibitors of two orthologues of DXS.

Masini T, Lacy B, Monjas L, Hawksley D, de Voogd AR, Illarionov B, Iqbal A, Leeper FJ, Fischer M, Kontoyianni M, Hirsch AK. Masini T, et al. Among authors: hirsch ak. Org Biomol Chem. 2015 Dec 14;13(46):11263-77. doi: 10.1039/c5ob01666e. Epub 2015 Sep 28. Org Biomol Chem. 2015. PMID: 26411373

9

Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry.

Mondal M, Radeva N, Fanlo-Virgós H, Otto S, Klebe G, Hirsch AK. Mondal M, et al. Among authors: hirsch ak. Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9422-6. doi: 10.1002/anie.201603074. Epub 2016 Jul 12. Angew Chem Int Ed Engl. 2016. PMID: 27400756 Free PMC article.

10

Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.

Mondal M, Unver MY, Pal A, Bakker M, Berrier SP, Hirsch AK. Mondal M, et al. Among authors: hirsch ak. Chemistry. 2016 Oct 10;22(42):14826-14830. doi: 10.1002/chem.201603001. Epub 2016 Sep 7. Chemistry. 2016. PMID: 27604032 Free PMC article.

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