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Nitro/nitrosyl-ruthenium complexes are potent and selective anti-Trypanosoma cruzi agents causing autophagy and necrotic parasite death.
Bastos TM, Barbosa MI, da Silva MM, da C Júnior JW, Meira CS, Guimaraes ET, Ellena J, Moreira DR, Batista AA, Soares MB. Bastos TM, et al. Among authors: moreira dr. Antimicrob Agents Chemother. 2014 Oct;58(10):6044-55. doi: 10.1128/AAC.02765-14. Epub 2014 Aug 4. Antimicrob Agents Chemother. 2014. PMID: 25092707 Free PMC article.
Evaluation of naphthoquinones identified the acetylated isolapachol as a potent and selective antiplasmodium agent.
Moreira DR, de Sá MS, Macedo TS, Menezes MN, Reys JR, Santana AE, Silva TL, Maia GL, Barbosa-Filho JM, Camara CA, da Silva TM, da Silva KN, Guimaraes ET, dos Santos RR, Goulart MO, Soares MB. Moreira DR, et al. J Enzyme Inhib Med Chem. 2015;30(4):615-21. doi: 10.3109/14756366.2014.958083. Epub 2014 Nov 28. J Enzyme Inhib Med Chem. 2015. PMID: 25431148 Free article.
Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: Cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole.
Corrêa RS, da Silva MM, Graminha AE, Meira CS, Santos JA, Moreira DR, Soares MB, Von Poelhsitz G, Castellano EE, Bloch C Jr, Cominetti MR, Batista AA. Corrêa RS, et al. Among authors: moreira dr. J Inorg Biochem. 2016 Mar;156:153-63. doi: 10.1016/j.jinorgbio.2015.12.024. Epub 2016 Jan 2. J Inorg Biochem. 2016. PMID: 26795676
Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells.
D'Sousa Costa CO, Araujo Neto JH, Baliza IRS, Dias RB, Valverde LF, Vidal MTA, Sales CBS, Rocha CAG, Moreira DRM, Soares MBP, Batista AA, Bezerra DP. D'Sousa Costa CO, et al. Oncotarget. 2017 Nov 1;8(61):104367-104392. doi: 10.18632/oncotarget.22248. eCollection 2017 Nov 28. Oncotarget. 2017. PMID: 29262647 Free PMC article.
A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells.
Oliveira MS, Barbosa MIF, de Souza TB, Moreira DRM, Martins FT, Villarreal W, Machado RP, Doriguetto AC, Soares MBP, Bezerra DP. Oliveira MS, et al. Redox Biol. 2019 Jan;20:182-194. doi: 10.1016/j.redox.2018.10.006. Epub 2018 Oct 12. Redox Biol. 2019. PMID: 30359932 Free PMC article.
95 results