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Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons.
J Neurosci. 2016 Jul 20;36(29):7693-706. doi: 10.1523/JNEUROSCI.0628-16.2016.
J Neurosci. 2016.
PMID: 27445146
Free PMC article.
Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide.
Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR.
Zunke F, et al. Among authors: toker nj.
Neuron. 2018 Jan 3;97(1):92-107.e10. doi: 10.1016/j.neuron.2017.12.012. Epub 2017 Dec 28.
Neuron. 2018.
PMID: 29290548
Free PMC article.
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Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.
Pérez Ortiz JM, Mollema N, Toker N, Adamski CJ, O'Callaghan B, Duvick L, Friedrich J, Walters MA, Strasser J, Hawkinson JE, Zoghbi HY, Henzler C, Orr HT, Lagalwar S.
Pérez Ortiz JM, et al.
Neurobiol Dis. 2018 Aug;116:93-105. doi: 10.1016/j.nbd.2018.05.002. Epub 2018 May 11.
Neurobiol Dis. 2018.
PMID: 29758256
Free PMC article.
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Intercellular Propagation and Aggregate Seeding of Mutant Ataxin-1.
Huang H, Toker N, Burr E, Okoro J, Moog M, Hearing C, Lagalwar S.
Huang H, et al.
J Mol Neurosci. 2022 Apr;72(4):708-718. doi: 10.1007/s12031-021-01944-1. Epub 2021 Nov 26.
J Mol Neurosci. 2022.
PMID: 34826062
Free PMC article.
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