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Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection.
Scott J, Sueiro-Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé JP, Krappmann S, Fowler S, Bignell E, Amich J. Scott J, et al. Among authors: amich j. Front Microbiol. 2019 Oct 9;10:2311. doi: 10.3389/fmicb.2019.02311. eCollection 2019. Front Microbiol. 2019. PMID: 31649650 Free PMC article.
Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.
Sueiro-Olivares M, Scott J, Gago S, Petrovic D, Kouroussis E, Zivanovic J, Yu Y, Strobel M, Cunha C, Thomson D, Fortune-Grant R, Thusek S, Bowyer P, Beilhack A, Carvalho A, Bignell E, Filipovic MR, Amich J. Sueiro-Olivares M, et al. Among authors: amich j. PLoS Biol. 2021 Jun 1;19(6):e3001247. doi: 10.1371/journal.pbio.3001247. eCollection 2021 Jun. PLoS Biol. 2021. PMID: 34061822 Free PMC article.
Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target.
van Rhijn N, Zhao C, Al-Furaji N, Storer I, Valero C, Gago S, Chown H, Baldin C, Fortune-Grant R, Shuraym HB, Ivanova L, Kniemeyer O, Krüger T, Bignell E, Goldman G, Amich J, Delneri D, Bowyer P, Brakhage A, Haas H, Bromley M. van Rhijn N, et al. Among authors: amich j. Res Sq [Preprint]. 2023 May 30:rs.3.rs-2960526. doi: 10.21203/rs.3.rs-2960526/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Jun 11;15(1):4984. doi: 10.1038/s41467-024-48592-8 PMID: 37398159 Free PMC article. Updated. Preprint.
Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging.
van Rhijn N, Zhao C, Al-Furaiji N, Storer ISR, Valero C, Gago S, Chown H, Baldin C, Grant RF, Bin Shuraym H, Ivanova L, Kniemeyer O, Krüger T, Bignell E, Goldman GH, Amich J, Delneri D, Bowyer P, Brakhage AA, Haas H, Bromley MJ. van Rhijn N, et al. Among authors: amich j. Nat Commun. 2024 Jun 11;15(1):4984. doi: 10.1038/s41467-024-48592-8. Nat Commun. 2024. PMID: 38862481 Free PMC article.
Author Correction: Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging.
van Rhijn N, Zhao C, Al-Furaiji N, Storer ISR, Valero C, Gago S, Chown H, Baldin C, Grant RF, Bin Shuraym H, Ivanova L, Kniemeyer O, Krüger T, Bignell E, Goldman GH, Amich J, Delneri D, Bowyer P, Brakhage AA, Haas H, Bromley MJ. van Rhijn N, et al. Among authors: amich j. Nat Commun. 2024 Aug 20;15(1):7126. doi: 10.1038/s41467-024-50129-y. Nat Commun. 2024. PMID: 39164238 Free PMC article. No abstract available.
Pathogenic fungi regulate immunity by inducing neutrophilic myeloid-derived suppressor cells.
Rieber N, Singh A, Öz H, Carevic M, Bouzani M, Amich J, Ost M, Ye Z, Ballbach M, Schäfer I, Mezger M, Klimosch SN, Weber AN, Handgretinger R, Krappmann S, Liese J, Engeholm M, Schüle R, Salih HR, Marodi L, Speckmann C, Grimbacher B, Ruland J, Brown GD, Beilhack A, Loeffler J, Hartl D. Rieber N, et al. Among authors: amich j. Cell Host Microbe. 2015 Apr 8;17(4):507-14. doi: 10.1016/j.chom.2015.02.007. Epub 2015 Mar 12. Cell Host Microbe. 2015. PMID: 25771792 Free PMC article.
mSphere of Influence: the Importance of Metabolism for Pathogen Adaptation to Host-Imposed Stresses.
Amich J. Amich J. mSphere. 2019 Aug 21;4(4):e00566-19. doi: 10.1128/mSphere.00566-19. mSphere. 2019. PMID: 31434750 Free PMC article.
Jorge Amich studies several aspects of sulfur and nitrogen metabolism in Aspergillus fumigatus, with the ultimate aim of identifying targets for the development of novel antifungals. In this mSphere of Influence article, he reflects on how "Sub-Telomere Directed Gene Expre …
Jorge Amich studies several aspects of sulfur and nitrogen metabolism in Aspergillus fumigatus, with the ultimate aim of identifying …
47 results