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Synthesis and in vitro opioid receptor functional antagonism of analogues of the selective kappa opioid receptor antagonist (3R)-7-hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
Cai TB, Zou Z, Thomas JB, Brieaddy L, Navarro HA, Carroll FI. Cai TB, et al. Among authors: navarro ha. J Med Chem. 2008 Mar 27;51(6):1849-60. doi: 10.1021/jm701344b. Epub 2008 Feb 29. J Med Chem. 2008. PMID: 18307295
Synthesis and in vitro opioid receptor functional antagonism of methyl-substituted analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic).
Cueva JP, Cai TB, Mascarella SW, Thomas JB, Navarro HA, Carroll FI. Cueva JP, et al. Among authors: navarro ha. J Med Chem. 2009 Dec 10;52(23):7463-72. doi: 10.1021/jm900756t. J Med Chem. 2009. PMID: 19954245 Free PMC article.
Analogues of (3R)-7-hydroxy-N-[(1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic). Synthesis and in vitro and in vivo opioid receptor antagonist activity.
Runyon SP, Brieaddy LE, Mascarella SW, Thomas JB, Navarro HA, Howard JL, Pollard GT, Carroll FI. Runyon SP, et al. Among authors: navarro ha. J Med Chem. 2010 Jul 22;53(14):5290-301. doi: 10.1021/jm1004978. J Med Chem. 2010. PMID: 20568781 Free PMC article.
132 results