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EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
Béguelin W, Teater M, Gearhart MD, Calvo Fernández MT, Goldstein RL, Cárdenas MG, Hatzi K, Rosen M, Shen H, Corcoran CM, Hamline MY, Gascoyne RD, Levine RL, Abdel-Wahab O, Licht JD, Shaknovich R, Elemento O, Bardwell VJ, Melnick AM. Béguelin W, et al. Among authors: gearhart md. Cancer Cell. 2016 Aug 8;30(2):197-213. doi: 10.1016/j.ccell.2016.07.006. Cancer Cell. 2016. PMID: 27505670 Free PMC article.
Metformin impairs trophoblast metabolism and differentiation in dose dependent manner.
Nashif SK, Mahr RM, Jena S, Jo S, Nelson AB, Sadowski D, Crawford PA, Puchalska P, Alejandro EU, Gearhart MD, Wernimont SA. Nashif SK, et al. Among authors: gearhart md. bioRxiv [Preprint]. 2023 Feb 17:2023.02.14.528531. doi: 10.1101/2023.02.14.528531. bioRxiv. 2023. Update in: Front Cell Dev Biol. 2023 May 12;11:1167097. doi: 10.3389/fcell.2023.1167097 PMID: 36824783 Free PMC article. Updated. Preprint.
Mitochondrial citrate metabolism and efflux regulates trophoblast differentiation.
Mahr RM, Jena S, Nashif SK, Nelson AB, Rauckhorst AJ, Rome FI, Sheldon RD, Hughey CC, Puchalska P, Gearhart MD, Taylor EB, Crawford PA, Wernimont SA. Mahr RM, et al. Among authors: gearhart md. bioRxiv [Preprint]. 2023 Jan 22:2023.01.22.525071. doi: 10.1101/2023.01.22.525071. bioRxiv. 2023. Update in: Sci Rep. 2023 May 6;13(1):7387. doi: 10.1038/s41598-023-34435-x PMID: 36711862 Free PMC article. Updated. Preprint.
A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.
Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD Jr, Xue F, Mason CE, Hiebert SW, Prive GG, Cerchietti L, Bardwell VJ, Elemento O, Melnick A. Hatzi K, et al. Among authors: gearhart md. Cell Rep. 2013 Aug 15;4(3):578-88. doi: 10.1016/j.celrep.2013.06.016. Epub 2013 Aug 1. Cell Rep. 2013. PMID: 23911289 Free PMC article.
Sexual cell-fate reprogramming in the ovary by DMRT1.
Lindeman RE, Gearhart MD, Minkina A, Krentz AD, Bardwell VJ, Zarkower D. Lindeman RE, et al. Among authors: gearhart md. Curr Biol. 2015 Mar 16;25(6):764-771. doi: 10.1016/j.cub.2015.01.034. Epub 2015 Feb 12. Curr Biol. 2015. PMID: 25683803 Free PMC article.
An ancient protein-DNA interaction underlying metazoan sex determination.
Murphy MW, Lee JK, Rojo S, Gearhart MD, Kurahashi K, Banerjee S, Loeuille GA, Bashamboo A, McElreavey K, Zarkower D, Aihara H, Bardwell VJ. Murphy MW, et al. Among authors: gearhart md. Nat Struct Mol Biol. 2015 Jun;22(6):442-51. doi: 10.1038/nsmb.3032. Epub 2015 May 25. Nat Struct Mol Biol. 2015. PMID: 26005864 Free PMC article.
53 results