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The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.
Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu KF, Wilkins SE, Yeh TL, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, Franz H, Sippl W, Lassmann S, Diederichs S, Schleicher E, Schofield CJ, Kawamura A, Schüle R, Jung M. Roatsch M, et al. Among authors: hoffmann i. ACS Chem Biol. 2019 Aug 16;14(8):1737-1750. doi: 10.1021/acschembio.9b00289. Epub 2019 Jul 19. ACS Chem Biol. 2019. PMID: 31287655
The role of histone demethylases in cancer therapy.
Hoffmann I, Roatsch M, Schmitt ML, Carlino L, Pippel M, Sippl W, Jung M. Hoffmann I, et al. Mol Oncol. 2012 Dec;6(6):683-703. doi: 10.1016/j.molonc.2012.07.004. Epub 2012 Aug 7. Mol Oncol. 2012. PMID: 22902149 Free PMC article. Review.
Mucosal melanomas of different anatomic sites share a common global DNA methylation profile with cutaneous melanoma but show location-dependent patterns of genetic and epigenetic alterations.
Jurmeister P, Wrede N, Hoffmann I, Vollbrecht C, Heim D, Hummel M, Wolkenstein P, Koch I, Heynol V, Schmitt WD, Thieme A, Teichmann D, Sers C, von Deimling A, Thierauf JC, von Laffert M, Klauschen F, Capper D. Jurmeister P, et al. Among authors: hoffmann i. J Pathol. 2022 Jan;256(1):61-70. doi: 10.1002/path.5808. Epub 2021 Oct 25. J Pathol. 2022. PMID: 34564861
Comparative investigation of cell cycle and immunomodulatory genes in mucosal and cutaneous melanomas: Preliminary data suggest a potential promising clinical role for p16 and the PD-1/PD-L1 axis.
Wrede N, Hoffmann I, Vollbrecht C, Koch I, Wolkenstein P, Klauschen F, Capper D, von Laffert M, Jurmeister P. Wrede N, et al. Among authors: hoffmann i. Pathol Res Pract. 2022 Jan;229:153689. doi: 10.1016/j.prp.2021.153689. Epub 2021 Nov 22. Pathol Res Pract. 2022. PMID: 34844086
Low Expression of RGS2 Promotes Poor Prognosis in High-Grade Serous Ovarian Cancer.
Ihlow J, Monjé N, Hoffmann I, Bischoff P, Sinn BV, Schmitt WD, Kunze CA, Darb-Esfahani S, Kulbe H, Braicu EI, Sehouli J, Denkert C, Horst D, Taube ET. Ihlow J, et al. Among authors: hoffmann i. Cancers (Basel). 2022 Sep 23;14(19):4620. doi: 10.3390/cancers14194620. Cancers (Basel). 2022. PMID: 36230542 Free PMC article.
Prognostic value of regulatory T cells and T helper 17 cells in high grade serous ovarian carcinoma.
Marchenko S, Piwonski I, Hoffmann I, Sinn BV, Kunze CA, Monjé N, Pohl J, Kulbe H, Schmitt WD, Darb-Esfahani S, Braicu EI, von Brünneck AC, Sehouli J, Denkert C, Horst D, Jöhrens K, Taube ET. Marchenko S, et al. Among authors: hoffmann i. J Cancer Res Clin Oncol. 2023 Jun;149(6):2523-2536. doi: 10.1007/s00432-022-04101-2. Epub 2022 Jun 28. J Cancer Res Clin Oncol. 2023. PMID: 35763108 Free PMC article.
Clinical characterisation and outcomes of human clade IIb mpox virus disease - a European multicentre observational cohort study (MOSAIC).
Pesonel E, Laouénan C, Guiraud L, Bourner J, Hoffmann I, Molino D, Tardivon C, Bachelet D, Mentré F, Amstutz A, Merson L, Rojek A, Cervantes Gonzalez M, Antinori A, Castagna A, Nozza S, Pourcher V, Libois A, Dunning J, Tacconelli E, Hites M, De La Calle Prieto F, Horby P, Yazdanpanah Y, Calmy A, Lescure FX, Olliaro P; MOSAIC Study Group. Pesonel E, et al. Among authors: hoffmann i. Clin Infect Dis. 2025 Jan 3:ciae657. doi: 10.1093/cid/ciae657. Online ahead of print. Clin Infect Dis. 2025. PMID: 39749987
563 results