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Page 1
Antileishmanial activity of new thiophene-indole hybrids: Design, synthesis, biological and cytotoxic evaluation, and chemometric studies.
Félix MB, de Souza ER, de Lima MDCA, Frade DKG, Serafim VL, Rodrigues KADF, Néris PLDN, Ribeiro FF, Scotti L, Scotti MT, de Aquino TM, Mendonça Junior FJB, de Oliveira MR. Félix MB, et al. Among authors: de aquino tm, de oliveira mr, de souza er, de lima mdca. Bioorg Med Chem. 2016 Sep 15;24(18):3972-3977. doi: 10.1016/j.bmc.2016.04.057. Epub 2016 Apr 26. Bioorg Med Chem. 2016. PMID: 27515718 Free article.
Preclinical data on morpholine (3,5-di-tertbutyl-4-hydroxyphenyl) methanone induced anxiolysis.
Cabral IB, de Lima Moreira CV, Rodrigues ACC, da Silva Moreira LK, Pereira JKA, Gomides CD, Lião LM, Machado LS, Vaz BG, da Cunha LC, de Oliveira Neto JR, da Silva-Júnior EF, de Aquino TM, da Silva Santos-Júnior PF, Silva ON, da Rocha FF, Costa EA, Menegatti R, Fajemiroye JO. Cabral IB, et al. Among authors: de lima moreira cv, de aquino tm, de oliveira neto jr. Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov;396(11):2957-2975. doi: 10.1007/s00210-023-02502-9. Epub 2023 Apr 25. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37097335
BACE-1 Inhibitors Targeting Alzheimer's Disease.
Monteiro KLC, Dos Santos Alcântara MG, Freire NML, Brandão EM, do Nascimento VL, Dos Santos Viana LM, de Aquino TM, da Silva-Júnior EF. Monteiro KLC, et al. Among authors: de aquino tm. Curr Alzheimer Res. 2023;20(3):131-148. doi: 10.2174/1567205020666230612155953. Curr Alzheimer Res. 2023. PMID: 37309767 Review.
Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids.
de Aquino TM, Liesen AP, da Silva RE, Lima VT, Carvalho CS, de Faria AR, de Araújo JM, de Lima JG, Alves AJ, de Melo EJ, Góes AJ. de Aquino TM, et al. Among authors: de melo ej, de araujo jm, de lima jg, de faria ar. Bioorg Med Chem. 2008 Jan 1;16(1):446-56. doi: 10.1016/j.bmc.2007.09.025. Epub 2007 Sep 18. Bioorg Med Chem. 2008. PMID: 17905587
Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles.
Liesen AP, de Aquino TM, Carvalho CS, Lima VT, de Araújo JM, de Lima JG, de Faria AR, de Melo EJ, Alves AJ, Alves EW, Alves AQ, Góes AJ. Liesen AP, et al. Among authors: de melo ej, de aquino tm, de araujo jm, de lima jg, de faria ar. Eur J Med Chem. 2010 Sep;45(9):3685-91. doi: 10.1016/j.ejmech.2010.05.017. Epub 2010 May 31. Eur J Med Chem. 2010. PMID: 20541294
Synthesis, structure-activity relationships (SAR) and in silico studies of coumarin derivatives with antifungal activity.
de Araújo RS, Guerra FQ, de O Lima E, de Simone CA, Tavares JF, Scotti L, Scotti MT, de Aquino TM, de Moura RO, Mendonça FJ, Barbosa-Filho JM. de Araújo RS, et al. Among authors: de moura ro, de aquino tm, de simone ca, de o lima e. Int J Mol Sci. 2013 Jan 10;14(1):1293-309. doi: 10.3390/ijms14011293. Int J Mol Sci. 2013. PMID: 23306152 Free PMC article.
2-Amino-thiophene derivatives present antileishmanial activity mediated by apoptosis and immunomodulation in vitro.
Rodrigues KA, Dias CN, Néris PL, Rocha Jda C, Scotti MT, Scotti L, Mascarenhas SR, Veras RC, de Medeiros IA, Keesen Tde S, de Oliveira TB, de Lima Mdo C, Balliano TL, de Aquino TM, de Moura RO, Mendonça Junior FJ, de Oliveira MR. Rodrigues KA, et al. Among authors: de moura ro, de aquino tm, de lima mdo c, de oliveira mr, de oliveira tb, de medeiros ia. Eur J Med Chem. 2015 Dec 1;106:1-14. doi: 10.1016/j.ejmech.2015.10.011. Epub 2015 Oct 17. Eur J Med Chem. 2015. PMID: 26513640
Molecular Modeling and Physicochemical Properties of Supramolecular Complexes of Limonene with α- and β-Cyclodextrins.
Dos Passos Menezes P, Dos Santos PB, Dória GA, de Sousa BM, Serafini MR, Nunes PS, Quintans-Júnior LJ, de Matos IL, Alves PB, Bezerra DP, Mendonça Júnior FJ, da Silva GF, de Aquino TM, de Souza Bento E, Scotti MT, Scotti L, de Souza Araujo AA. Dos Passos Menezes P, et al. Among authors: de aquino tm, de sousa bm, de matos il, de souza bento e, de souza araujo aa. AAPS PharmSciTech. 2017 Feb;18(1):49-57. doi: 10.1208/s12249-016-0516-0. Epub 2016 Apr 12. AAPS PharmSciTech. 2017. PMID: 27073031
Dynamic Simulation, Docking and DFT Studies Applied to a Set of Anti-Acetylcholinesterase Inhibitors in the enzyme β-Secretase (BACE-1): An Important Therapeutic Target in Alzheimer`s disease.
Silva-Junior EF, Barcellos Franca PH, Quintans-Junior LJ, Mendonca-Junior FJB, Scotti L, Scotti MT, de Aquino TM, de Araujo-Junior JX. Silva-Junior EF, et al. Among authors: de araujo junior jx, de aquino tm. Curr Comput Aided Drug Des. 2017 Nov 10;13(4):266-274. doi: 10.2174/1573409913666170406150905. Curr Comput Aided Drug Des. 2017. PMID: 28382866
Molecular Docking Studies Applied to a Dataset of Cruzain Inhibitors.
da Silva-Junior EF, Barcellos Franca PH, Ribeiro FF, Bezerra Mendonca-Junior FJ, Scotti L, Scotti MT, de Aquino TM, de Araujo-Junior JX. da Silva-Junior EF, et al. Among authors: de araujo junior jx, de aquino tm. Curr Comput Aided Drug Des. 2018;14(1):68-78. doi: 10.2174/1573409913666170519112758. Curr Comput Aided Drug Des. 2018. PMID: 28523999
48 results