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Vascular smooth muscle cell contractile protein expression is increased through protein kinase G-dependent and -independent pathways by glucose-6-phosphate dehydrogenase inhibition and deficiency.
Chettimada S, Joshi SR, Dhagia V, Aiezza A 2nd, Lincoln TM, Gupte R, Miano JM, Gupte SA. Chettimada S, et al. Among authors: dhagia v. Am J Physiol Heart Circ Physiol. 2016 Oct 1;311(4):H904-H912. doi: 10.1152/ajpheart.00335.2016. Epub 2016 Aug 12. Am J Physiol Heart Circ Physiol. 2016. PMID: 27521420 Free PMC article.
20-HETE-induced mitochondrial superoxide production and inflammatory phenotype in vascular smooth muscle is prevented by glucose-6-phosphate dehydrogenase inhibition.
Lakhkar A, Dhagia V, Joshi SR, Gotlinger K, Patel D, Sun D, Wolin MS, Schwartzman ML, Gupte SA. Lakhkar A, et al. Among authors: dhagia v. Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1107-17. doi: 10.1152/ajpheart.00961.2015. Epub 2016 Feb 26. Am J Physiol Heart Circ Physiol. 2016. PMID: 26921441 Free PMC article.
Involvement of gap junctions between smooth muscle cells in sustained hypoxic pulmonary vasoconstriction development: a potential role for 15-HETE and 20-HETE.
Kizub IV, Lakhkar A, Dhagia V, Joshi SR, Jiang H, Wolin MS, Falck JR, Koduru SR, Errabelli R, Jacobs ER, Schwartzman ML, Gupte SA. Kizub IV, et al. Among authors: dhagia v. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 15;310(8):L772-83. doi: 10.1152/ajplung.00377.2015. Epub 2016 Feb 19. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26895643 Free PMC article.
Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.
Hashimoto R, Lanier GM, Dhagia V, Joshi SR, Jordan A, Waddell I, Tuder R, Stenmark KR, Wolin MS, McMurtry IF, Gupte SA. Hashimoto R, et al. Among authors: dhagia v. Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L386-L401. doi: 10.1152/ajplung.00327.2019. Epub 2020 Jan 8. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31913656 Free PMC article.
Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.
Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell I, Leopold J, Hu CJ, McMurtry IF, D'Alessandro A, Stenmark KR, Gupte SA. Joshi SR, et al. Among authors: dhagia v. Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L773-L786. doi: 10.1152/ajplung.00001.2020. Epub 2020 Mar 11. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 32159369 Free PMC article.
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