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Page 1
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA. Lund AW, et al. Among authors: spranger s. J Clin Invest. 2016 Sep 1;126(9):3389-402. doi: 10.1172/JCI79434. Epub 2016 Aug 15. J Clin Invest. 2016. PMID: 27525437 Free PMC article.
Once upon a prime: DCs shape cancer immunity.
Zagorulya M, Spranger S. Zagorulya M, et al. Among authors: spranger s. Trends Cancer. 2023 Feb;9(2):172-184. doi: 10.1016/j.trecan.2022.10.006. Epub 2022 Nov 7. Trends Cancer. 2023. PMID: 36357313 Free PMC article. Review.
Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies.
Lax BM, Palmeri JR, Lutz EA, Sheen A, Stinson JA, Duhamel L, Santollani L, Kennedy A, Rothschilds AM, Spranger S, Sansom DM, Wittrup KD. Lax BM, et al. Among authors: spranger s. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2300895120. doi: 10.1073/pnas.2300895120. Epub 2023 Jul 24. Proc Natl Acad Sci U S A. 2023. PMID: 37487077 Free PMC article.
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.
Zagorulya M, Yim L, Morgan DM, Edwards A, Torres-Mejia E, Momin N, McCreery CV, Zamora IL, Horton BL, Fox JG, Wittrup KD, Love JC, Spranger S. Zagorulya M, et al. Among authors: spranger s. Immunity. 2023 Feb 14;56(2):386-405.e10. doi: 10.1016/j.immuni.2023.01.010. Epub 2023 Feb 2. Immunity. 2023. PMID: 36736322 Free PMC article.
Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation.
Bhagchandani SH, Vohidov F, Milling LE, Tong EY, Brown CM, Ramseier ML, Liu B, Fessenden TB, Nguyen HV, Kiel GR, Won L, Langer RS, Spranger S, Shalek AK, Irvine DJ, Johnson JA. Bhagchandani SH, et al. Among authors: spranger s. Sci Adv. 2023 Apr 21;9(16):eadg2239. doi: 10.1126/sciadv.adg2239. Epub 2023 Apr 19. Sci Adv. 2023. PMID: 37075115 Free PMC article.
Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer.
Mahat DB, Kumra H, Castro SA, Metcalf E, Nguyen K, Morisue R, Ho WW, Chen I, Sullivan B, Yim LK, Singh A, Fu J, Waterton SK, Cheng YC, Roberge S, Moiso E, Chauhan VP, Silva HM, Spranger S, Jain RK, Sharp PA. Mahat DB, et al. Among authors: spranger s. bioRxiv [Preprint]. 2024 Aug 30:2024.08.28.609802. doi: 10.1101/2024.08.28.609802. bioRxiv. 2024. PMID: 39257788 Free PMC article. Preprint.
147 results