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TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression.
Bjerre C, Vinther L, Belling KC, Würtz SØ, Yadav R, Lademann U, Rigina O, Do KN, Ditzel HJ, Lykkesfeldt AE, Wang J, Nielsen HB, Brünner N, Gupta R, Schrohl AS, Stenvang J. Bjerre C, et al. Among authors: brunner n. Tumour Biol. 2013 Dec;34(6):3839-51. doi: 10.1007/s13277-013-0969-7. Epub 2013 Jul 24. Tumour Biol. 2013. PMID: 23881388
TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells.
Hekmat O, Munk S, Fogh L, Yadav R, Francavilla C, Horn H, Würtz SØ, Schrohl AS, Damsgaard B, Rømer MU, Belling KC, Jensen NF, Gromova I, Bekker-Jensen DB, Moreira JM, Jensen LJ, Gupta R, Lademann U, Brünner N, Olsen JV, Stenvang J. Hekmat O, et al. Among authors: brunner n. J Proteome Res. 2013 Sep 6;12(9):4136-51. doi: 10.1021/pr400457u. Epub 2013 Aug 21. J Proteome Res. 2013. PMID: 23909892
Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties.
Lin X, Li J, Yin G, Zhao Q, Elias D, Lykkesfeldt AE, Stenvang J, Brünner N, Wang J, Yang H, Bolund L, Ditzel HJ. Lin X, et al. Among authors: brunner n. Breast Cancer Res. 2013 Dec 19;15(6):R119. doi: 10.1186/bcr3588. Breast Cancer Res. 2013. PMID: 24355041 Free PMC article.
Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways.
Hansen SN, Westergaard D, Thomsen MB, Vistesen M, Do KN, Fogh L, Belling KC, Wang J, Yang H, Gupta R, Ditzel HJ, Moreira J, Brünner N, Stenvang J, Schrohl AS. Hansen SN, et al. Among authors: brunner n. Tumour Biol. 2015 Jun;36(6):4327-38. doi: 10.1007/s13277-015-3072-4. Epub 2015 Jan 18. Tumour Biol. 2015. PMID: 25596703
594 results