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PARP3 is a sensor of nicked nucleosomes and monoribosylates histone H2B(Glu2).
Grundy GJ, Polo LM, Zeng Z, Rulten SL, Hoch NC, Paomephan P, Xu Y, Sweet SM, Thorne AW, Oliver AW, Matthews SJ, Pearl LH, Caldecott KW. Grundy GJ, et al. Among authors: rulten sl. Nat Commun. 2016 Aug 17;7:12404. doi: 10.1038/ncomms12404. Nat Commun. 2016. PMID: 27530147 Free PMC article.
XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia.
Hoch NC, Hanzlikova H, Rulten SL, Tétreault M, Komulainen E, Ju L, Hornyak P, Zeng Z, Gittens W, Rey SA, Staras K, Mancini GM, McKinnon PJ, Wang ZQ, Wagner JD; Care4Rare Canada Consortium; Yoon G, Caldecott KW. Hoch NC, et al. Among authors: rulten sl. Nature. 2017 Jan 5;541(7635):87-91. doi: 10.1038/nature20790. Epub 2016 Dec 21. Nature. 2017. PMID: 28002403 Free PMC article.
DNA strand break repair and neurodegeneration.
Rulten SL, Caldecott KW. Rulten SL, et al. DNA Repair (Amst). 2013 Aug;12(8):558-67. doi: 10.1016/j.dnarep.2013.04.008. Epub 2013 May 24. DNA Repair (Amst). 2013. PMID: 23712058 Free article. Review.
31 results