Hoch DG - Search Results

1

Divergent synthesis and identification of the cellular targets of deoxyelephantopins.

Lagoutte R, Serba C, Abegg D, Hoch DG, Adibekian A, Winssinger N. Lagoutte R, et al. Among authors: hoch dg. Nat Commun. 2016 Aug 19;7:12470. doi: 10.1038/ncomms12470. Nat Commun. 2016. PMID: 27539788 Free PMC article.

2

Cysteine-specific Chemical Proteomics: From Target Identification to Drug Discovery.

Hoch DG, Abegg D, Wang C, Shuster A, Adibekian A. Hoch DG, et al. Chimia (Aarau). 2016 Nov 30;70(11):764-767. doi: 10.2533/chimia.2016.764. Chimia (Aarau). 2016. PMID: 28661335 Free article. Review.

3

Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT.

Wang C, Abegg D, Hoch DG, Adibekian A. Wang C, et al. Among authors: hoch dg. Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2911-5. doi: 10.1002/anie.201511301. Epub 2016 Jan 22. Angew Chem Int Ed Engl. 2016. PMID: 26798972

4

Strained Cyclic Disulfides Enable Cellular Uptake by Reacting with the Transferrin Receptor.

Abegg D, Gasparini G, Hoch DG, Shuster A, Bartolami E, Matile S, Adibekian A. Abegg D, et al. Among authors: hoch dg. J Am Chem Soc. 2017 Jan 11;139(1):231-238. doi: 10.1021/jacs.6b09643. Epub 2016 Dec 21. J Am Chem Soc. 2017. PMID: 28001050

5

Cysteine-reactive probes and their use in chemical proteomics.

Hoch DG , Abegg D , Adibekian A . Hoch DG , et al. Chem Commun (Camb). 2018 May 1;54(36):4501-4512. doi: 10.1039/c8cc01485j. Chem Commun (Camb). 2018. PMID: 29645055

6

Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids.

Davis DC, Hoch DG, Wu L, Abegg D, Martin BS, Zhang ZY, Adibekian A, Dai M. Davis DC, et al. Among authors: hoch dg. J Am Chem Soc. 2018 Dec 19;140(50):17465-17473. doi: 10.1021/jacs.8b07652. Epub 2018 Dec 6. J Am Chem Soc. 2018. PMID: 30461272 Free PMC article.

7

Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex.

Hoch DG, Abegg D, Hannich JT, Pechalrieu D, Shuster A, Dwyer BG, Wang C, Zhang X, You Q, Riezman H, Adibekian A. Hoch DG, et al. Cell Chem Biol. 2020 May 21;27(5):586-597.e12. doi: 10.1016/j.chembiol.2020.03.008. Epub 2020 Apr 23. Cell Chem Biol. 2020. PMID: 32330443 Free article.

8

Total Synthesis and Target Identification of the Curcusone Diterpenes.

Cui C, Dwyer BG, Liu C, Abegg D, Cai ZJ, Hoch DG, Yin X, Qiu N, Liu JQ, Adibekian A, Dai M. Cui C, et al. Among authors: hoch dg. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11. J Am Chem Soc. 2021. PMID: 33705657 Free PMC article.

9

A Designed Small Molecule Inhibitor of a Non-Coding RNA Sensitizes HER2 Negative Cancers to Herceptin.

Costales MG, Hoch DG, Abegg D, Childs-Disney JL, Velagapudi SP, Adibekian A, Disney MD. Costales MG, et al. Among authors: hoch dg. J Am Chem Soc. 2019 Feb 20;141(7):2960-2974. doi: 10.1021/jacs.8b10558. Epub 2019 Feb 6. J Am Chem Soc. 2019. PMID: 30726072 Free PMC article.

10

Chemoproteomics-Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism.

Dwyer BG, Wang C, Abegg D, Racioppo B, Qiu N, Zhao Z, Pechalrieu D, Shuster A, Hoch DG, Adibekian A. Dwyer BG, et al. Among authors: hoch dg. Angew Chem Int Ed Engl. 2021 Feb 8;60(6):3071-3079. doi: 10.1002/anie.202011163. Epub 2020 Dec 7. Angew Chem Int Ed Engl. 2021. PMID: 33035395

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