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Increasing the performance of pooled CRISPR-Cas9 drop-out screening.
Cross BC, Lawo S, Archer CR, Hunt JR, Yarker JL, Riccombeni A, Little AS, McCarthy NJ, Moore JD. Cross BC, et al. Among authors: little as. Sci Rep. 2016 Aug 22;6:31782. doi: 10.1038/srep31782. Sci Rep. 2016. PMID: 27545104 Free PMC article.
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.
Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ. Little AS, et al. Sci Signal. 2011 Mar 29;4(166):ra17. doi: 10.1126/scisignal.2001752. Sci Signal. 2011. Corrected and republished in: Sci Signal. 2011;4(170):er2. doi: 10.1126/scisignal.4170er2 PMID: 21447798 Corrected and republished.
Knockdown of KRAS reversed AZD6244 resistance in HCT116 cells as well as reduced the activation of ERK1/2 and protein kinase B; however, the combined inhibition of ERK1/2 and phosphatidylinositol 3-kinase signaling had little effect on AZD6244 resistance, sug …
Knockdown of KRAS reversed AZD6244 resistance in HCT116 cells as well as reduced the activation of ERK1/2 and protein kinase B …
A correction to the research article titled: "Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells" by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P. A. W. Edwards, P. D. Smith, S. J. Cook.
Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ. Little AS, et al. Sci Signal. 2011;4(170):er2. doi: 10.1126/scisignal.4170er2. Sci Signal. 2011. PMID: 21674991
Knockdown of KRAS reversed AZD6244 resistance in HCT116 cells as well as reduced the activation of ERK1/2 and protein kinase B; however, the combined inhibition of ERK1/2 and phosphatidylinositol 3-kinase signaling had little effect on AZD6244 resistance, sug …
Knockdown of KRAS reversed AZD6244 resistance in HCT116 cells as well as reduced the activation of ERK1/2 and protein kinase B …
Cushing's Disease Clinical Phenotype and Tumor Behavior Vary with Age: Diagnostic and Perioperative Implications.
Salcedo-Sifuentes JE, Shih R, Heaney AP, Bergsneider M, Wang MB, Donangelo I, Lee J, Delery W, Karsy M, Kshettry VR, Yuen KCJ, Evans JJ, Barkhoudarian G, Pacione DR, Gardner PA, Fernandez-Miranda JC, Benjamin C, Zada G, Rennert RC, Silverstein JM, Chicoine MR, Kim J, Li G, Little AS, Kim W. Salcedo-Sifuentes JE, et al. Among authors: little as. J Clin Endocrinol Metab. 2025 Jan 2:dgae904. doi: 10.1210/clinem/dgae904. Online ahead of print. J Clin Endocrinol Metab. 2025. PMID: 39745928
Extracranial-intracranial bypass using a cephalic vein graft for iatrogenic internal carotid artery injury during functional endoscopic sinus surgery: illustrative case.
Wehbi N, Rahmani R, Benet A, Kim JE, Scherschinski L, Catapano JS, Anthony AW, Jadhav AP, Ducruet AF, Albuquerque FC, Little AS, Santarelli GD, Stevens SM, Jategaonkar AA, Lawton MT. Wehbi N, et al. Among authors: little as. J Neurosurg Case Lessons. 2024 Oct 14;8(16):CASE24222. doi: 10.3171/CASE24222. Print 2024 Oct 14. J Neurosurg Case Lessons. 2024. PMID: 39401459 Free PMC article.
153 results