van den Heuvel J - Search Results

1

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C, Zippin JH, van den Heuvel J, Glickman JF, Steegborn C, Levin LR, Buck J. Ramos-Espiritu L, et al. Among authors: van den heuvel j. Nat Chem Biol. 2016 Oct;12(10):838-44. doi: 10.1038/nchembio.2151. Epub 2016 Aug 22. Nat Chem Biol. 2016. PMID: 27547922 Free PMC article.

2

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C. Kleinboelting S, et al. Among authors: van den heuvel j. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3727-32. doi: 10.1073/pnas.1322778111. Epub 2014 Feb 24. Proc Natl Acad Sci U S A. 2014. PMID: 24567411 Free PMC article.

3

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a mammalian type 10 adenylyl cyclase.

Kleinboelting S, van den Heuvel J, Kambach C, Weyand M, Leipelt M, Steegborn C. Kleinboelting S, et al. Among authors: van den heuvel j. Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):467-9. doi: 10.1107/S2053230X14004014. Epub 2014 Mar 25. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 24699740 Free PMC article.

4

Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution.

Kleinboelting S, van den Heuvel J, Steegborn C. Kleinboelting S, et al. Among authors: van den heuvel j. FEBS J. 2014 Sep;281(18):4151-64. doi: 10.1111/febs.12913. Epub 2014 Jul 28. FEBS J. 2014. PMID: 25040695 Free article.

5

Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C. Kleinboelting S, et al. Among authors: van den heuvel j. J Biol Chem. 2016 Apr 29;291(18):9776-84. doi: 10.1074/jbc.M115.708255. Epub 2016 Mar 9. J Biol Chem. 2016. PMID: 26961873 Free PMC article.

6

Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10).

Fushimi M, Buck H, Balbach M, Gorovyy A, Ferreira J, Rossetti T, Kaur N, Levin LR, Buck J, Quast J, van den Heuvel J, Steegborn C, Finkin-Groner E, Kargman S, Michino M, Foley MA, Miller M, Liverton NJ, Huggins DJ, Meinke PT. Fushimi M, et al. Among authors: van den heuvel j. ACS Med Chem Lett. 2021 Jul 14;12(8):1283-1287. doi: 10.1021/acsmedchemlett.1c00273. eCollection 2021 Aug 12. ACS Med Chem Lett. 2021. PMID: 34413957 Free PMC article.

7

Assembling Multi-subunit Complexes Using Mammalian Expression.

Baser B, van den Heuvel J. Baser B, et al. Among authors: van den heuvel j. Adv Exp Med Biol. 2016;896:225-38. doi: 10.1007/978-3-319-27216-0_15. Adv Exp Med Biol. 2016. PMID: 27165329 Review.

8

Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes.

Iphöfer A, Kummer A, Nimtz M, Ritter A, Arnold T, Frank R, van den Heuvel J, Kessler BM, Jänsch L, Franke R. Iphöfer A, et al. Among authors: van den heuvel j. Chembiochem. 2012 Jul 9;13(10):1416-20. doi: 10.1002/cbic.201200261. Epub 2012 Jun 11. Chembiochem. 2012. PMID: 22689415 No abstract available.

9

Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.

Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K, Pessler F. Chen F, et al. Among authors: van den heuvel j. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20644-20654. doi: 10.1073/pnas.1908770116. Epub 2019 Sep 23. Proc Natl Acad Sci U S A. 2019. PMID: 31548418 Free PMC article.

10

High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.

Kügler J, Schmelz S, Gentzsch J, Haid S, Pollmann E, van den Heuvel J, Franke R, Pietschmann T, Heinz DW, Collins J. Kügler J, et al. Among authors: van den heuvel j. J Biol Chem. 2012 Nov 9;287(46):39224-32. doi: 10.1074/jbc.M112.393843. Epub 2012 Sep 10. J Biol Chem. 2012. PMID: 22965230 Free PMC article.

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