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The cohesin subunit Rad21 is a negative regulator of hematopoietic self-renewal through epigenetic repression of Hoxa7 and Hoxa9.
Fisher JB, Peterson J, Reimer M, Stelloh C, Pulakanti K, Gerbec ZJ, Abel AM, Strouse JM, Strouse C, McNulty M, Malarkannan S, Crispino JD, Milanovich S, Rao S. Fisher JB, et al. Among authors: pulakanti k. Leukemia. 2017 Mar;31(3):712-719. doi: 10.1038/leu.2016.240. Epub 2016 Aug 24. Leukemia. 2017. PMID: 27554164 Free PMC article.
DOT1L inhibitors block abnormal self-renewal induced by cohesin loss.
Heimbruch KE, Fisher JB, Stelloh CT, Phillips E, Reimer MH Jr, Wargolet AJ, Meyer AE, Pulakanti K, Viny AD, Loppnow JJ, Levine RL, Pulikkan JA, Zhu N, Rao S. Heimbruch KE, et al. Among authors: pulakanti k. Sci Rep. 2021 Mar 31;11(1):7288. doi: 10.1038/s41598-021-86646-9. Sci Rep. 2021. PMID: 33790356 Free PMC article.
27 results