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RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation.
Jones RA, Robinson TJ, Liu JC, Shrestha M, Voisin V, Ju Y, Chung PE, Pellecchia G, Fell VL, Bae S, Muthuswamy L, Datti A, Egan SE, Jiang Z, Leone G, Bader GD, Schimmer A, Zacksenhaus E. Jones RA, et al. Among authors: datti a. J Clin Invest. 2016 Oct 3;126(10):3739-3757. doi: 10.1172/JCI81568. Epub 2016 Aug 29. J Clin Invest. 2016. PMID: 27571409 Free PMC article.
Identification of CDC25 as a Common Therapeutic Target for Triple-Negative Breast Cancer.
Liu JC, Granieri L, Shrestha M, Wang DY, Vorobieva I, Rubie EA, Jones R, Ju Y, Pellecchia G, Jiang Z, Palmerini CA, Ben-David Y, Egan SE, Woodgett JR, Bader GD, Datti A, Zacksenhaus E. Liu JC, et al. Among authors: datti a. Cell Rep. 2018 Apr 3;23(1):112-126. doi: 10.1016/j.celrep.2018.03.039. Cell Rep. 2018. PMID: 29617654 Free PMC article.
Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.
Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PED, Deng T, Chen NJ, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus E. Jiang Z, et al. Among authors: datti a. EMBO J. 2022 Feb 15;41(4):e106825. doi: 10.15252/embj.2020106825. Epub 2022 Jan 13. EMBO J. 2022. PMID: 35023164 Free PMC article.
Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.
Sukhai MA, Prabha S, Hurren R, Rutledge AC, Lee AY, Sriskanthadevan S, Sun H, Wang X, Skrtic M, Seneviratne A, Cusimano M, Jhas B, Gronda M, MacLean N, Cho EE, Spagnuolo PA, Sharmeen S, Gebbia M, Urbanus M, Eppert K, Dissanayake D, Jonet A, Dassonville-Klimpt A, Li X, Datti A, Ohashi PS, Wrana J, Rogers I, Sonnet P, Ellis WY, Corey SJ, Eaves C, Minden MD, Wang JC, Dick JE, Nislow C, Giaever G, Schimmer AD. Sukhai MA, et al. Among authors: datti a. J Clin Invest. 2013 Jan;123(1):315-28. doi: 10.1172/JCI64180. Epub 2012 Dec 3. J Clin Invest. 2013. PMID: 23202731 Free PMC article. Clinical Trial.
Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.
Skrtić M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, Datti A, Ketela T, Moffat J, Robinson BH, Cameron JH, Wrana J, Eaves CJ, Minden MD, Wang JC, Dick JE, Humphries K, Nislow C, Giaever G, Schimmer AD. Skrtić M, et al. Among authors: datti a. Cancer Cell. 2011 Nov 15;20(5):674-88. doi: 10.1016/j.ccr.2011.10.015. Cancer Cell. 2011. PMID: 22094260 Free PMC article.
104 results