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A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS. Janssen E, et al. Among authors: hartwig j. J Clin Invest. 2016 Oct 3;126(10):3837-3851. doi: 10.1172/JCI85774. Epub 2016 Sep 6. J Clin Invest. 2016. PMID: 27599296 Free PMC article.
WIP is critical for T cell responsiveness to IL-2.
Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi MK, Hartwig J, Geha RS. Le Bras S, et al. Among authors: hartwig j. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7519-24. doi: 10.1073/pnas.0806410106. Epub 2009 Apr 9. Proc Natl Acad Sci U S A. 2009. PMID: 19359486 Free PMC article.
WIP regulates N-WASP-mediated actin polymerization and filopodium formation.
Martinez-Quiles N, Rohatgi R, Antón IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N. Martinez-Quiles N, et al. Among authors: hartwig jh. Nat Cell Biol. 2001 May;3(5):484-91. doi: 10.1038/35074551. Nat Cell Biol. 2001. PMID: 11331876
B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.
Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. Recher M, et al. Among authors: hartwig j. Blood. 2012 Mar 22;119(12):2819-28. doi: 10.1182/blood-2011-09-379412. Epub 2012 Feb 1. Blood. 2012. PMID: 22302739 Free PMC article.
711 results