Irvine DJ - Search Results

1

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.

Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS. Janssen E, et al. Among authors: irvine dj. J Clin Invest. 2016 Oct 3;126(10):3837-3851. doi: 10.1172/JCI85774. Epub 2016 Sep 6. J Clin Invest. 2016. PMID: 27599296 Free PMC article.

2

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.

Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML. Kumari S, et al. Among authors: irvine dj. Elife. 2015 Mar 11;4:e04953. doi: 10.7554/eLife.04953. Elife. 2015. PMID: 25758716 Free PMC article.

3

DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.

Janssen E, Kumari S, Tohme M, Ullas S, Barrera V, Tas JM, Castillo-Rama M, Bronson RT, Usmani SM, Irvine DJ, Mempel TR, Geha RS. Janssen E, et al. Among authors: irvine dj. JCI Insight. 2017 Oct 5;2(19):e94298. doi: 10.1172/jci.insight.94298. JCI Insight. 2017. PMID: 28978806 Free PMC article.

4

Not All T Cell Synapses Are Built the Same Way.

Kumari S, Colin-York H, Irvine DJ, Fritzsche M. Kumari S, et al. Among authors: irvine dj. Trends Immunol. 2019 Nov;40(11):977-980. doi: 10.1016/j.it.2019.09.009. Epub 2019 Oct 20. Trends Immunol. 2019. PMID: 31645298 Free PMC article. Review.

5

DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8⁺ T Cell Compartment by Negatively Regulating Tonic TCR Triggering.

Mahajan VS, Demissie E, Alsufyani F, Kumari S, Yuen GJ, Viswanadham V, Huang A, Tran JQ, Moon JJ, Irvine DJ, Pillai S. Mahajan VS, et al. Among authors: irvine dj. J Immunol. 2020 Jan 1;204(1):49-57. doi: 10.4049/jimmunol.1900440. Epub 2019 Nov 18. J Immunol. 2020. PMID: 31740487 Free PMC article.

6

Cytoskeletal tension actively sustains the migratory T-cell synaptic contact.

Kumari S, Mak M, Poh YC, Tohme M, Watson N, Melo M, Janssen E, Dustin M, Geha R, Irvine DJ. Kumari S, et al. Among authors: irvine dj. EMBO J. 2020 Mar 2;39(5):e102783. doi: 10.15252/embj.2019102783. Epub 2020 Jan 2. EMBO J. 2020. PMID: 31894880 Free PMC article.

7

Enhancing Adoptive Cell Therapy of Cancer through Targeted Delivery of Small-Molecule Immunomodulators to Internalizing or Noninternalizing Receptors.

Zheng Y, Tang L, Mabardi L, Kumari S, Irvine DJ. Zheng Y, et al. Among authors: irvine dj. ACS Nano. 2017 Mar 28;11(3):3089-3100. doi: 10.1021/acsnano.7b00078. Epub 2017 Mar 1. ACS Nano. 2017. PMID: 28231431 Free PMC article.

8

WASP facilitates tumor mechanosensitivity in T lymphocytes.

Mandal S, Melo M, Gordiichuk P, Acharya S, Poh YC, Li N, Aung A, Dane EL, Irvine DJ, Kumari S. Mandal S, et al. Among authors: irvine dj. bioRxiv [Preprint]. 2023 Oct 4:2023.10.02.560434. doi: 10.1101/2023.10.02.560434. bioRxiv. 2023. PMID: 37873483 Free PMC article. Preprint.

9

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells.

Jones RB, Mueller S, Kumari S, Vrbanac V, Genel S, Tager AM, Allen TM, Walker BD, Irvine DJ. Jones RB, et al. Among authors: irvine dj. Biomaterials. 2017 Feb;117:44-53. doi: 10.1016/j.biomaterials.2016.11.048. Epub 2016 Nov 25. Biomaterials. 2017. PMID: 27936416 Free PMC article.

10

Beyond antigens and adjuvants: formulating future vaccines.

Moyer TJ, Zmolek AC, Irvine DJ. Moyer TJ, et al. Among authors: irvine dj. J Clin Invest. 2016 Mar 1;126(3):799-808. doi: 10.1172/JCI81083. Epub 2016 Mar 1. J Clin Invest. 2016. PMID: 26928033 Free PMC article. Review.

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