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New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study.
Tommasino C, Gambardella L, Buoncervello M, Griffin RJ, Golding BT, Alberton M, Macchia D, Spada M, Cerbelli B, d'Amati G, Malorni W, Gabriele L, Giammarioli AM. Tommasino C, et al. Among authors: gambardella l. J Exp Clin Cancer Res. 2016 Sep 6;35(1):137. doi: 10.1186/s13046-016-0409-9. J Exp Clin Cancer Res. 2016. PMID: 27599543 Free PMC article.
Pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) induces apoptosis of freshly isolated human T lymphocytes, bypassing CD95/Fas molecule but involving its intrinsic pathway.
Pierdominici M, Giammarioli AM, Gambardella L, De Felice M, Quinti I, Iacobini M, Carbonari M, Malorni W, Giovannetti A. Pierdominici M, et al. Among authors: gambardella l. J Pharmacol Exp Ther. 2005 Dec;315(3):1046-57. doi: 10.1124/jpet.105.086736. Epub 2005 Sep 12. J Pharmacol Exp Ther. 2005. PMID: 16157660
138 results