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The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells.
Thijssen R, Ter Burg J, van Bochove GG, de Rooij MF, Kuil A, Jansen MH, Kuijpers TW, Baars JW, Virone-Oddos A, Spaargaren M, Egile C, van Oers MH, Eldering E, Kersten MJ, Kater AP. Thijssen R, et al. Among authors: eldering e. Leukemia. 2016 Sep;30(9):1963. doi: 10.1038/leu.2016.184. Leukemia. 2016. PMID: 27600169 No abstract available.
CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack.
Kater AP, Evers LM, Remmerswaal EB, Jaspers A, Oosterwijk MF, van Lier RA, van Oers MH, Eldering E. Kater AP, et al. Among authors: eldering e. Br J Haematol. 2004 Nov;127(4):404-15. doi: 10.1111/j.1365-2141.2004.05225.x. Br J Haematol. 2004. PMID: 15521917 Free article.
149 results