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Physiological Expression of AMPKγ2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice.
Yang X, Mudgett J, Bou-About G, Champy MF, Jacobs H, Monassier L, Pavlovic G, Sorg T, Herault Y, Petit-Demoulière B, Lu K, Feng W, Wang H, Ma LJ, Askew R, Erion MD, Kelley DE, Myers RW, Li C, Guan HP. Yang X, et al. Among authors: li c. J Biol Chem. 2016 Nov 4;291(45):23428-23439. doi: 10.1074/jbc.M116.738591. Epub 2016 Sep 12. J Biol Chem. 2016. PMID: 27621313 Free PMC article.
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Myers RW, Guan HP, Ehrhart J, Petrov A, Prahalada S, Tozzo E, Yang X, Kurtz MM, Trujillo M, Gonzalez Trotter D, Feng D, Xu S, Eiermann G, Holahan MA, Rubins D, Conarello S, Niu X, Souza SC, Miller C, Liu J, Lu K, Feng W, Li Y, Painter RE, Milligan JA, He H, Liu F, Ogawa A, Wisniewski D, Rohm RJ, Wang L, Bunzel M, Qian Y, Zhu W, Wang H, Bennet B, LaFranco Scheuch L, Fernandez GE, Li C, Klimas M, Zhou G, van Heek M, Biftu T, Weber A, Kelley DE, Thornberry N, Erion MD, Kemp DM, Sebhat IK. Myers RW, et al. Among authors: li c, li y. Science. 2017 Aug 4;357(6350):507-511. doi: 10.1126/science.aah5582. Epub 2017 Jul 13. Science. 2017. PMID: 28705990
Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects.
Miller CO, Yang X, Lu K, Cao J, Herath K, Rosahl TW, Askew R, Pavlovic G, Zhou G, Li C, Akiyama TE. Miller CO, et al. Among authors: li c. Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E386-E393. doi: 10.1152/ajpendo.00027.2018. Epub 2018 Jun 5. Am J Physiol Endocrinol Metab. 2018. PMID: 29870677 Free article.
Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase.
Feng D, Biftu T, Romero FA, Kekec A, Dropinski J, Kassick A, Xu S, Kurtz MM, Gollapudi A, Shao Q, Yang X, Lu K, Zhou G, Kemp D, Myers RW, Guan HP, Trujillo ME, Li C, Weber A, Sebhat IK. Feng D, et al. Among authors: li c. ACS Med Chem Lett. 2017 Dec 1;9(1):39-44. doi: 10.1021/acsmedchemlett.7b00417. eCollection 2018 Jan 11. ACS Med Chem Lett. 2017. PMID: 29348809 Free PMC article.
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Singh SB, Kang L, Nawrocki AR, Zhou D, Wu M, Previs S, Miller C, Liu H, Hines CD, Madeira M, Cao J, Herath K, Spears LD, Semenkovich CF, Wang L, Kelley DE, Li C, Guan HP. Singh SB, et al. Among authors: li c. PLoS One. 2016 Oct 3;11(10):e0164133. doi: 10.1371/journal.pone.0164133. eCollection 2016. PLoS One. 2016. PMID: 27695056 Free PMC article.
Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Wu M, Singh SB, Wang J, Chung CC, Salituro G, Karanam BV, Lee SH, Powles M, Ellsworth KP, Lassman ME, Miller C, Myers RW, Tota MR, Zhang BB, Li C. Wu M, et al. Among authors: li c. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5378-83. doi: 10.1073/pnas.1002588108. Epub 2011 Mar 9. Proc Natl Acad Sci U S A. 2011. PMID: 21389266 Free PMC article.
Correction: The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.
Singh SB, Kang L, Nawrocki AR, Zhou D, Wu M, Previs S, Miller C, Liu H, Hines CD, Madeira M, Cao J, Herath K, Spears LD, Semenkovich CF, Wang L, Kelley DE, Li C, Guan HP. Singh SB, et al. Among authors: li c. PLoS One. 2017 Jan 19;12(1):e0170721. doi: 10.1371/journal.pone.0170721. eCollection 2017. PLoS One. 2017. PMID: 28103304 Free PMC article.
Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.
Liu W, Shao PP, Liang GB, Bawiec J, He J, Aster SD, Wu M, Chicchi G, Wang J, Tsao KL, Shang J, Salituro G, Zhou YP, Li C, Akiyama TE, Metzger DE, Murphy BA, Howard AD, Weber AE, Duffy JL. Liu W, et al. Among authors: li c. ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. doi: 10.1021/acsmedchemlett.8b00305. eCollection 2018 Nov 8. ACS Med Chem Lett. 2018. PMID: 30429949 Free PMC article.
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