Guantai EM - Search Results

1

Computer-Aided Drug Discovery Approaches against the Tropical Infectious Diseases Malaria, Tuberculosis, Trypanosomiasis, and Leishmaniasis.

Njogu PM, Guantai EM, Pavadai E, Chibale K. Njogu PM, et al. Among authors: guantai em. ACS Infect Dis. 2016 Jan 8;2(1):8-31. doi: 10.1021/acsinfecdis.5b00093. Epub 2015 Nov 16. ACS Infect Dis. 2016. PMID: 27622945

2

Chloroquine resistance: proposed mechanisms and countermeasures.

Guantai E, Chibale K. Guantai E, et al. Curr Drug Deliv. 2010 Oct;7(4):312-23. doi: 10.2174/156720110793360577. Curr Drug Deliv. 2010. PMID: 20695842

3

How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

Guantai E, Chibale K. Guantai E, et al. Malar J. 2011 Mar 15;10 Suppl 1(Suppl 1):S2. doi: 10.1186/1475-2875-10-S1-S2. Malar J. 2011. PMID: 21411013 Free PMC article. Review.

4

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.

Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Hans RH, et al. Among authors: guantai em. Bioorg Med Chem Lett. 2010 Feb 1;20(3):942-4. doi: 10.1016/j.bmcl.2009.12.062. Epub 2009 Dec 23. Bioorg Med Chem Lett. 2010. PMID: 20045640

5

Antiplasmodial and antitumor activity of dihydroartemisinin analogs derived via the aza-Michael addition reaction.

Feng TS, Guantai EM, Nell MJ, van Rensburg CE, Hoppe HC, Chibale K. Feng TS, et al. Among authors: guantai em. Bioorg Med Chem Lett. 2011 May 15;21(10):2882-6. doi: 10.1016/j.bmcl.2011.03.090. Epub 2011 Mar 30. Bioorg Med Chem Lett. 2011. PMID: 21489789

6

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. Guantai EM, et al. Bioorg Med Chem. 2010 Dec 1;18(23):8243-56. doi: 10.1016/j.bmc.2010.10.009. Epub 2010 Oct 31. Bioorg Med Chem. 2010. PMID: 21044845

7

Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents.

Tacon C, Guantai EM, Smith PJ, Chibale K. Tacon C, et al. Among authors: guantai em. Bioorg Med Chem. 2012 Jan 15;20(2):893-902. doi: 10.1016/j.bmc.2011.11.060. Epub 2011 Dec 3. Bioorg Med Chem. 2012. PMID: 22196513

8

Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum.

Feng TS, Guantai EM, Nell M, van Rensburg CE, Ncokazi K, Egan TJ, Hoppe HC, Chibale K. Feng TS, et al. Among authors: guantai em. Biochem Pharmacol. 2011 Aug 1;82(3):236-47. doi: 10.1016/j.bcp.2011.04.018. Epub 2011 May 8. Biochem Pharmacol. 2011. PMID: 21596024

9

Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. Guantai EM, et al. J Med Chem. 2011 May 26;54(10):3637-49. doi: 10.1021/jm200149e. Epub 2011 May 5. J Med Chem. 2011. PMID: 21500839 Free PMC article.

10

Extracting molecular information from African natural products to facilitate unique African-led drug-discovery efforts.

Chibale K, Guantai EM, Masimirembwa C. Chibale K, et al. Among authors: guantai em. Future Med Chem. 2011 Mar;3(3):257-61. doi: 10.4155/fmc.10.299. Future Med Chem. 2011. PMID: 21446839 No abstract available.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

18 results

Search Page

Filters