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The KEAP1-NRF2 pathway: Targets for therapy and role in cancer.
Adinolfi S, Patinen T, Jawahar Deen A, Pitkänen S, Härkönen J, Kansanen E, Küblbeck J, Levonen AL. Adinolfi S, et al. Among authors: levonen al. Redox Biol. 2023 Jul;63:102726. doi: 10.1016/j.redox.2023.102726. Epub 2023 Apr 29. Redox Biol. 2023. PMID: 37146513 Free PMC article. Review.
A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies.
Härkönen J, Pölönen P, Deen AJ, Selvarajan I, Teppo HR, Dimova EY, Kietzmann T, Ahtiainen M, Väyrynen JP, Väyrynen SA, Elomaa H, Tynkkynen N, Eklund T, Kuopio T, Talvitie EM, Taimen P, Kallajoki M, Kaikkonen MU, Heinäniemi M, Levonen AL. Härkönen J, et al. Among authors: levonen al. Redox Biol. 2023 May;61:102644. doi: 10.1016/j.redox.2023.102644. Epub 2023 Feb 27. Redox Biol. 2023. PMID: 36867945 Free PMC article.
LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis: Insight From Mouse Models.
Cedó L, Metso J, Santos D, García-León A, Plana N, Sabate-Soler S, Rotllan N, Rivas-Urbina A, Méndez-Lara KA, Tondo M, Girona J, Julve J, Pallarès V, Benitez-Amaro A, Llorente-Cortes V, Pérez A, Gómez-Coronado D, Ruotsalainen AK, Levonen AL, Sanchez-Quesada JL, Masana L, Kovanen PT, Jauhiainen M, Lee-Rueckert M, Blanco-Vaca F, Escolà-Gil JC. Cedó L, et al. Among authors: levonen al. Circ Res. 2020 Aug 28;127(6):778-792. doi: 10.1161/CIRCRESAHA.119.316424. Epub 2020 Jun 4. Circ Res. 2020. PMID: 32495699
Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2.
Lämsä V, Levonen AL, Sormunen R, Yamamoto M, Hakkola J. Lämsä V, et al. Among authors: levonen al. Toxicol Sci. 2012 Nov;130(1):132-44. doi: 10.1093/toxsci/kfs237. Epub 2012 Aug 2. Toxicol Sci. 2012. PMID: 22859313
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Leinonen HM, Ruotsalainen AK, Määttä AM, Laitinen HM, Kuosmanen SM, Kansanen E, Pikkarainen JT, Lappalainen JP, Samaranayake H, Lesch HP, Kaikkonen MU, Ylä-Herttuala S, Levonen AL. Leinonen HM, et al. Among authors: levonen al. Cancer Res. 2012 Dec 1;72(23):6227-35. doi: 10.1158/0008-5472.CAN-12-1166. Epub 2012 Oct 4. Cancer Res. 2012. PMID: 23041549
The absence of macrophage Nrf2 promotes early atherogenesis.
Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Mäkinen PI, Heinonen SE, Laitinen HM, Heikkilä J, Vatanen T, Hörkkö S, Yamamoto M, Ylä-Herttuala S, Jauhiainen M, Levonen AL. Ruotsalainen AK, et al. Among authors: levonen al. Cardiovasc Res. 2013 Apr 1;98(1):107-15. doi: 10.1093/cvr/cvt008. Epub 2013 Jan 22. Cardiovasc Res. 2013. PMID: 23341579
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