Sawyer WS - Search Results

1

Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.

Dovala D, Rath CM, Hu Q, Sawyer WS, Shia S, Elling RA, Knapp MS, Metzger LE 4th. Dovala D, et al. Among authors: sawyer ws. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6064-E6071. doi: 10.1073/pnas.1610746113. Epub 2016 Sep 28. Proc Natl Acad Sci U S A. 2016. PMID: 27681620 Free PMC article.

2

Rapid analysis of protein expression and solubility with the SpyTag-SpyCatcher system.

Dovala D, Sawyer WS, Rath CM, Metzger LE 4th. Dovala D, et al. Among authors: sawyer ws. Protein Expr Purif. 2016 Jan;117:44-51. doi: 10.1016/j.pep.2015.09.021. Epub 2015 Sep 21. Protein Expr Purif. 2016. PMID: 26405011 Free article.

3

Toxic Accumulation of LPS Pathway Intermediates Underlies the Requirement of LpxH for Growth of Acinetobacter baumannii ATCC 19606.

Richie DL, Takeoka KT, Bojkovic J, Metzger LE 4th, Rath CM, Sawyer WS, Wei JR, Dean CR. Richie DL, et al. Among authors: sawyer ws. PLoS One. 2016 Aug 15;11(8):e0160918. doi: 10.1371/journal.pone.0160918. eCollection 2016. PLoS One. 2016. PMID: 27526195 Free PMC article.

4

LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates.

Wei JR, Richie DL, Mostafavi M, Metzger LE 4th, Rath CM, Sawyer WS, Takeoka KT, Dean CR. Wei JR, et al. Among authors: sawyer ws. mSphere. 2017 Jul 26;2(4):e00199-17. doi: 10.1128/mSphere.00199-17. eCollection 2017 Jul-Aug. mSphere. 2017. PMID: 28815210 Free PMC article.

5

Characterization of an Acinetobacter baumannii lptD Deletion Strain: Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis.

Bojkovic J, Richie DL, Six DA, Rath CM, Sawyer WS, Hu Q, Dean CR. Bojkovic J, et al. Among authors: sawyer ws. J Bacteriol. 2015 Dec 14;198(4):731-41. doi: 10.1128/JB.00639-15. J Bacteriol. 2015. PMID: 26668262 Free PMC article.

6

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis.

Mostafavi M, Wang L, Xie L, Takeoka KT, Richie DL, Casey F, Ruzin A, Sawyer WS, Rath CM, Wei JR, Dean CR. Mostafavi M, et al. Among authors: sawyer ws. mSphere. 2018 Oct 31;3(5):e00508-18. doi: 10.1128/mSphere.00508-18. mSphere. 2018. PMID: 30381354 Free PMC article.

7

Targeted lipopolysaccharide biosynthetic intermediate analysis with normal-phase liquid chromatography mass spectrometry.

Sawyer WS, Wang L, Uehara T, Tamrakar P, Prathapam R, Mostafavi M, Metzger LE 4th, Feng B, Baxter Rath CM. Sawyer WS, et al. PLoS One. 2019 Feb 8;14(2):e0211803. doi: 10.1371/journal.pone.0211803. eCollection 2019. PLoS One. 2019. PMID: 30735516 Free PMC article.

8

Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.

Han W, Ma X, Balibar CJ, Baxter Rath CM, Benton B, Bermingham A, Casey F, Chie-Leon B, Cho MK, Frank AO, Frommlet A, Ho CM, Lee PS, Li M, Lingel A, Ma S, Merritt H, Ornelas E, De Pascale G, Prathapam R, Prosen KR, Rasper D, Ruzin A, Sawyer WS, Shaul J, Shen X, Shia S, Steffek M, Subramanian S, Vo J, Wang F, Wartchow C, Uehara T. Han W, et al. Among authors: sawyer ws. J Am Chem Soc. 2020 Mar 4;142(9):4445-4455. doi: 10.1021/jacs.9b13530. Epub 2020 Feb 17. J Am Chem Soc. 2020. PMID: 32064871

9

Molecular Probes for the Determination of Subcellular Compound Exposure Profiles in Gram-Negative Bacteria.

Spangler B, Dovala D, Sawyer WS, Thompson KV, Six DA, Reck F, Feng BY. Spangler B, et al. Among authors: sawyer ws. ACS Infect Dis. 2018 Sep 14;4(9):1355-1367. doi: 10.1021/acsinfecdis.8b00093. Epub 2018 Jun 15. ACS Infect Dis. 2018. PMID: 29846057

10

Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.

Skepper CK, Armstrong D, Balibar CJ, Bauer D, Bellamacina C, Benton BM, Bussiere D, De Pascale G, De Vicente J, Dean CR, Dhumale B, Fisher LM, Fuller J, Fulsunder M, Holder LM, Hu C, Kantariya B, Lapointe G, Leeds JA, Li X, Lu P, Lvov A, Ma S, Madhavan S, Malekar S, McKenney D, Mergo W, Metzger L, Moser HE, Mutnick D, Noeske J, Osborne C, Patel A, Patel D, Patel T, Prajapati K, Prosen KR, Reck F, Richie DL, Rico A, Sanderson MR, Satasia S, Sawyer WS, Selvarajah J, Shah N, Shanghavi K, Shu W, Thompson KV, Traebert M, Vala A, Vala L, Veselkov DA, Vo J, Wang M, Widya M, Williams SL, Xu Y, Yue Q, Zang R, Zhou B, Rivkin A. Skepper CK, et al. Among authors: sawyer ws. J Med Chem. 2020 Jul 23;63(14):7773-7816. doi: 10.1021/acs.jmedchem.0c00347. Epub 2020 Jul 7. J Med Chem. 2020. PMID: 32634310

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