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Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.
Rosenbluh J, Mercer J, Shrestha Y, Oliver R, Tamayo P, Doench JG, Tirosh I, Piccioni F, Hartenian E, Horn H, Fagbami L, Root DE, Jaffe J, Lage K, Boehm JS, Hahn WC. Rosenbluh J, et al. Among authors: doench jg. Cell Syst. 2016 Sep 28;3(3):302-316.e4. doi: 10.1016/j.cels.2016.09.001. Cell Syst. 2016. PMID: 27684187 Free PMC article.
Genome-scale CRISPR-Cas9 knockout screening in human cells.
Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Shalem O, et al. Among authors: doench jg. Science. 2014 Jan 3;343(6166):84-87. doi: 10.1126/science.1247005. Epub 2013 Dec 12. Science. 2014. PMID: 24336571 Free PMC article.
HDAC5 controls MEF2C-driven sclerostin expression in osteocytes.
Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM. Wein MN, et al. J Bone Miner Res. 2015 Mar;30(3):400-11. doi: 10.1002/jbmr.2381. J Bone Miner Res. 2015. PMID: 25271055 Free PMC article.
Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.
Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT. Egan ES, et al. Among authors: doench jg. Science. 2015 May 8;348(6235):711-4. doi: 10.1126/science.aaa3526. Science. 2015. PMID: 25954012 Free PMC article.
187 results