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Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.
Atienzar FA, Blomme EA, Chen M, Hewitt P, Kenna JG, Labbe G, Moulin F, Pognan F, Roth AB, Suter-Dick L, Ukairo O, Weaver RJ, Will Y, Dambach DM. Atienzar FA, et al. Among authors: pognan f. Biomed Res Int. 2016;2016:9737920. doi: 10.1155/2016/9737920. Epub 2016 Sep 5. Biomed Res Int. 2016. PMID: 27689095 Free PMC article. Review.
Optimizing drug discovery by Investigative Toxicology: Current and future trends.
Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T. Beilmann M, et al. Among authors: pognan f. ALTEX. 2019;36(2):289-313. doi: 10.14573/altex.1808181. Epub 2018 Dec 20. ALTEX. 2019. PMID: 30570669 Free article.
The evolving role of investigative toxicology in the pharmaceutical industry.
Pognan F, Beilmann M, Boonen HCM, Czich A, Dear G, Hewitt P, Mow T, Oinonen T, Roth A, Steger-Hartmann T, Valentin JP, Van Goethem F, Weaver RJ, Newham P. Pognan F, et al. Nat Rev Drug Discov. 2023 Apr;22(4):317-335. doi: 10.1038/s41573-022-00633-x. Epub 2023 Feb 13. Nat Rev Drug Discov. 2023. PMID: 36781957 Free PMC article. Review.
Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina.
Dorgau B, Georgiou M, Chaudhary A, Moya-Molina M, Collin J, Queen R, Hilgen G, Davey T, Hewitt P, Schmitt M, Kustermann S, Pognan F, Steel DH, Sernagor E, Armstrong L, Lako M. Dorgau B, et al. Among authors: pognan f. Stem Cells Transl Med. 2022 Mar 17;11(2):159-177. doi: 10.1093/stcltm/szab010. Stem Cells Transl Med. 2022. PMID: 35298655 Free PMC article.
Bile acids in drug induced liver injury: Key players and surrogate markers.
Schadt HS, Wolf A, Pognan F, Chibout SD, Merz M, Kullak-Ublick GA. Schadt HS, et al. Among authors: pognan f. Clin Res Hepatol Gastroenterol. 2016 Jun;40(3):257-266. doi: 10.1016/j.clinre.2015.12.017. Epub 2016 Feb 10. Clin Res Hepatol Gastroenterol. 2016. PMID: 26874804 Free article. Review.
Inroads to predict in vivo toxicology-an introduction to the eTOX Project.
Briggs K, Cases M, Heard DJ, Pastor M, Pognan F, Sanz F, Schwab CH, Steger-Hartmann T, Sutter A, Watson DK, Wichard JD. Briggs K, et al. Among authors: pognan f. Int J Mol Sci. 2012;13(3):3820-3846. doi: 10.3390/ijms13033820. Epub 2012 Mar 21. Int J Mol Sci. 2012. PMID: 22489185 Free PMC article. Review.
Investigative safety science as a competitive advantage for Pharma.
Moggs J, Moulin P, Pognan F, Brees D, Leonard M, Busch S, Cordier A, Heard DJ, Kammüller M, Merz M, Bouchard P, Chibout SD. Moggs J, et al. Among authors: pognan f. Expert Opin Drug Metab Toxicol. 2012 Sep;8(9):1071-82. doi: 10.1517/17425255.2012.693914. Epub 2012 Jul 7. Expert Opin Drug Metab Toxicol. 2012. PMID: 22769724 Review.
Legacy data sharing to improve drug safety assessment: the eTOX project.
Sanz F, Pognan F, Steger-Hartmann T, Díaz C; eTOX; Cases M, Pastor M, Marc P, Wichard J, Briggs K, Watson DK, Kleinöder T, Yang C, Amberg A, Beaumont M, Brookes AJ, Brunak S, Cronin MTD, Ecker GF, Escher S, Greene N, Guzmán A, Hersey A, Jacques P, Lammens L, Mestres J, Muster W, Northeved H, Pinches M, Saiz J, Sajot N, Valencia A, van der Lei J, Vermeulen NPE, Vock E, Wolber G, Zamora I. Sanz F, et al. Among authors: pognan f. Nat Rev Drug Discov. 2017 Dec;16(12):811-812. doi: 10.1038/nrd.2017.177. Epub 2017 Oct 13. Nat Rev Drug Discov. 2017. PMID: 29026211 Free article.
53 results