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mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.
Paschoal VA, Amano MT, Belchior T, Magdalon J, Chimin P, Andrade ML, Ortiz-Silva M, Castro É, Yamashita AS, Rosa Neto JC, Câmara NO, Festuccia WT. Paschoal VA, et al. Among authors: castro e. Immunobiology. 2017 Feb;222(2):261-271. doi: 10.1016/j.imbio.2016.09.014. Epub 2016 Sep 28. Immunobiology. 2017. PMID: 27692982
Adipocyte mTORC1 deficiency promotes adipose tissue inflammation and NLRP3 inflammasome activation via oxidative stress and de novo ceramide synthesis.
Chimin P, Andrade ML, Belchior T, Paschoal VA, Magdalon J, Yamashita AS, Castro É, Castoldi A, Chaves-Filho AB, Yoshinaga MY, Miyamoto S, Câmara NO, Festuccia WT. Chimin P, et al. Among authors: castro e. J Lipid Res. 2017 Sep;58(9):1797-1807. doi: 10.1194/jlr.M074518. Epub 2017 Jul 5. J Lipid Res. 2017. PMID: 28679588 Free PMC article.
Fish Oil Protects Wild Type and Uncoupling Protein 1-Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure.
Oliveira TE, Castro É, Belchior T, Andrade ML, Chaves-Filho AB, Peixoto AS, Moreno MF, Ortiz-Silva M, Moreira RJ, Inague A, Yoshinaga MY, Miyamoto S, Moustaid-Moussa N, Festuccia WT. Oliveira TE, et al. Among authors: castro e. Mol Nutr Food Res. 2019 Apr;63(7):e1800813. doi: 10.1002/mnfr.201800813. Epub 2019 Jan 17. Mol Nutr Food Res. 2019. PMID: 30632684
Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids.
Moreira RJ, Castro É, Oliveira TE, Belchior T, Peixoto AS, Chaves-Filho AB, Moreno MF, Lima JD, Yoshinaga M, Miyamoto S, Morais MRPT, Zorn TMT, Cogliati B, Iwai LK, Palmisano G, Cabral FJ, Festuccia W. Moreira RJ, et al. Among authors: castro e. Mol Nutr Food Res. 2020 Apr;64(7):e1900833. doi: 10.1002/mnfr.201900833. Epub 2020 Feb 3. Mol Nutr Food Res. 2020. PMID: 31978277
PPARγ-induced upregulation of subcutaneous fat adiponectin secretion, glyceroneogenesis and BCAA oxidation requires mTORC1 activity.
Andrade ML, Gilio GR, Perandini LA, Peixoto AS, Moreno MF, Castro É, Oliveira TE, Vieira TS, Ortiz-Silva M, Thomazelli CA, Chaves-Filho AB, Belchior T, Chimin P, Magdalon J, Ivison R, Pant D, Tsai L, Yoshinaga MY, Miyamoto S, Festuccia WT. Andrade ML, et al. Among authors: castro e. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158967. doi: 10.1016/j.bbalip.2021.158967. Epub 2021 May 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2021. PMID: 34004356 Free PMC article.
Adipocyte-specific mTORC2 deficiency impairs BAT and iWAT thermogenic capacity without affecting glucose uptake and energy expenditure in cold-acclimated mice.
Castro É, Vieira TS, Oliveira TE, Ortiz-Silva M, Andrade ML, Tomazelli CA, Peixoto AS, Sobrinho CR, Moreno MF, Gilio GR, Moreira RJ, Guimarães RC, Perandini LA, Chimin P, Reckziegel P, Moretti EH, Steiner AA, Laplante M, Festuccia WT. Castro É, et al. Am J Physiol Endocrinol Metab. 2021 Nov 1;321(5):E592-E605. doi: 10.1152/ajpendo.00587.2020. Epub 2021 Sep 20. Am J Physiol Endocrinol Metab. 2021. PMID: 34541875 Free article.
Futile cycle of β-oxidation and de novo lipogenesis are associated with essential fatty acids depletion in lipoatrophy.
Chaves-Filho AB, Peixoto AS, Castro É, Oliveira TE, Perandini LA, Moreira RJ, da Silva RP, da Silva BP, Moretti EH, Steiner AA, Miyamoto S, Yoshinaga MY, Festuccia WT. Chaves-Filho AB, et al. Among authors: castro e. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Mar;1868(3):159264. doi: 10.1016/j.bbalip.2022.159264. Epub 2022 Dec 17. Biochim Biophys Acta Mol Cell Biol Lipids. 2023. PMID: 36535597
1,692 results