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Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression.
Malki K, Tosto MG, Mouriño-Talín H, Rodríguez-Lorenzo S, Pain O, Jumhaboy I, Liu T, Parpas P, Newman S, Malykh A, Carboni L, Uher R, McGuffin P, Schalkwyk LC, Bryson K, Herbster M. Malki K, et al. Among authors: mcguffin p. Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):235-250. doi: 10.1002/ajmg.b.32494. Epub 2016 Oct 1. Am J Med Genet B Neuropsychiatr Genet. 2017. PMID: 27696737 Free PMC article.
Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.
Malki K, Uher R, Paya-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng MY, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig IW, Lewis CM, McGuffin P, Schalkwyk LC. Malki K, et al. Among authors: mcguffin p. Biol Psychiatry. 2011 Feb 15;69(4):360-5. doi: 10.1016/j.biopsych.2010.08.011. Epub 2010 Oct 20. Biol Psychiatry. 2011. PMID: 20970119 Clinical Trial.
Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response.
Powell TR, Schalkwyk LC, Heffernan AL, Breen G, Lawrence T, Price T, Farmer AE, Aitchison KJ, Craig IW, Danese A, Lewis C, McGuffin P, Uher R, Tansey KE, D'Souza UM. Powell TR, et al. Among authors: mcguffin p. Eur Neuropsychopharmacol. 2013 Sep;23(9):1105-14. doi: 10.1016/j.euroneuro.2012.09.009. Epub 2012 Nov 9. Eur Neuropsychopharmacol. 2013. PMID: 23142150 Clinical Trial.
625 results