Nguyen LT - Search Results

1

Clinical Pharmacokinetics and Pharmacodynamics of Cabozantinib.

Lacy SA, Miles DR, Nguyen LT. Lacy SA, et al. Among authors: nguyen lt. Clin Pharmacokinet. 2017 May;56(5):477-491. doi: 10.1007/s40262-016-0461-9. Clin Pharmacokinet. 2017. PMID: 27734291 Review.

2

Population pharmacokinetic/pharmacodynamic modeling of tumor growth kinetics in medullary thyroid cancer patients receiving cabozantinib.

Miles DR, Wada DR, Jumbe NL, Lacy SA, Nguyen LT. Miles DR, et al. Among authors: nguyen lt. Anticancer Drugs. 2016 Apr;27(4):328-41. doi: 10.1097/CAD.0000000000000330. Anticancer Drugs. 2016. PMID: 26825867

3

Assessment of cabozantinib treatment on QT interval in a phase 3 study in medullary thyroid cancer: evaluation of indirect QT effects mediated through treatment-induced changes in serum electrolytes.

Miles DR, Lacy SA, Wada DR, Milwee S, Yaron Y, Nguyen LT. Miles DR, et al. Among authors: nguyen lt. Cancer Chemother Pharmacol. 2017 Aug;80(2):295-306. doi: 10.1007/s00280-017-3349-y. Epub 2017 Jun 20. Cancer Chemother Pharmacol. 2017. PMID: 28634649 Clinical Trial.

4

Pharmacokinetic (PK) drug interaction studies of cabozantinib: Effect of CYP3A inducer rifampin and inhibitor ketoconazole on cabozantinib plasma PK and effect of cabozantinib on CYP2C8 probe substrate rosiglitazone plasma PK.

Nguyen L, Holland J, Miles D, Engel C, Benrimoh N, O'Reilly T, Lacy S. Nguyen L, et al. J Clin Pharmacol. 2015 Sep;55(9):1012-23. doi: 10.1002/jcph.510. Epub 2015 Jun 2. J Clin Pharmacol. 2015. PMID: 25854986 Clinical Trial.

5

Evaluation of the effect of food and gastric pH on the single-dose pharmacokinetics of cabozantinib in healthy adult subjects.

Nguyen L, Holland J, Mamelok R, Laberge MK, Grenier J, Swearingen D, Armas D, Lacy S. Nguyen L, et al. J Clin Pharmacol. 2015 Nov;55(11):1293-302. doi: 10.1002/jcph.526. Epub 2015 Jun 26. J Clin Pharmacol. 2015. PMID: 25907407 Clinical Trial.

6

Metabolism and Disposition of Cabozantinib in Healthy Male Volunteers and Pharmacologic Characterization of Its Major Metabolites.

Lacy S, Hsu B, Miles D, Aftab D, Wang R, Nguyen L. Lacy S, et al. Drug Metab Dispos. 2015 Aug;43(8):1190-207. doi: 10.1124/dmd.115.063610. Epub 2015 May 26. Drug Metab Dispos. 2015. PMID: 26015560

7

Population Pharmacokinetic Model of Cabozantinib in Patients with Medullary Thyroid Carcinoma and Its Application to an Exposure-Response Analysis.

Miles D, Jumbe NL, Lacy S, Nguyen L. Miles D, et al. Clin Pharmacokinet. 2016 Jan;55(1):93-105. doi: 10.1007/s40262-015-0295-x. Clin Pharmacokinet. 2016. PMID: 26149244

8

Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Cabozantinib.

Nguyen L, Holland J, Ramies D, Mamelok R, Benrimoh N, Ciric S, Marbury T, Preston RA, Heuman DM, Gavis E, Lacy S. Nguyen L, et al. J Clin Pharmacol. 2016 Sep;56(9):1130-40. doi: 10.1002/jcph.714. Epub 2016 Mar 23. J Clin Pharmacol. 2016. PMID: 26865195

9

Pharmacokinetics of cabozantinib tablet and capsule formulations in healthy adults.

Nguyen L, Benrimoh N, Xie Y, Offman E, Lacy S. Nguyen L, et al. Anticancer Drugs. 2016 Aug;27(7):669-78. doi: 10.1097/CAD.0000000000000366. Anticancer Drugs. 2016. PMID: 27139820 Clinical Trial.

10

Population exposure-response analysis of cabozantinib efficacy and safety endpoints in patients with renal cell carcinoma.

Lacy S, Nielsen J, Yang B, Miles D, Nguyen L, Hutmacher M. Lacy S, et al. Cancer Chemother Pharmacol. 2018 Jun;81(6):1061-1070. doi: 10.1007/s00280-018-3579-7. Epub 2018 Apr 17. Cancer Chemother Pharmacol. 2018. PMID: 29667066 Free PMC article. Clinical Trial.

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