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PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression.
Horiuchi D, Camarda R, Zhou AY, Yau C, Momcilovic O, Balakrishnan S, Corella AN, Eyob H, Kessenbrock K, Lawson DA, Marsh LA, Anderton BN, Rohrberg J, Kunder R, Bazarov AV, Yaswen P, McManus MT, Rugo HS, Werb Z, Goga A. Horiuchi D, et al. Among authors: goga a. Nat Med. 2016 Nov;22(11):1321-1329. doi: 10.1038/nm.4213. Epub 2016 Oct 24. Nat Med. 2016. PMID: 27775705 Free PMC article.
Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.
Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT. Huang TH, et al. Among authors: goga a. J Biol Chem. 2009 Jul 3;284(27):18515-24. doi: 10.1074/jbc.M109.006676. Epub 2009 May 6. J Biol Chem. 2009. PMID: 19419954 Free PMC article.
miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma.
Swarbrick A, Woods SL, Shaw A, Balakrishnan A, Phua Y, Nguyen A, Chanthery Y, Lim L, Ashton LJ, Judson RL, Huskey N, Blelloch R, Haber M, Norris MD, Lengyel P, Hackett CS, Preiss T, Chetcuti A, Sullivan CS, Marcusson EG, Weiss W, L'Etoile N, Goga A. Swarbrick A, et al. Among authors: goga a. Nat Med. 2010 Oct;16(10):1134-40. doi: 10.1038/nm.2227. Epub 2010 Sep 26. Nat Med. 2010. PMID: 20871609 Free PMC article.
Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways.
Horiuchi D, Huskey NE, Kusdra L, Wohlbold L, Merrick KA, Zhang C, Creasman KJ, Shokat KM, Fisher RP, Goga A. Horiuchi D, et al. Among authors: goga a. Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):E1019-27. doi: 10.1073/pnas.1111317109. Epub 2012 Apr 3. Proc Natl Acad Sci U S A. 2012. PMID: 22474407 Free PMC article.
281 results