Buckner FS - Search Results

1

Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.

Huang W, Zhang Z, Barros-Álvarez X, Koh CY, Ranade RM, Gillespie JR, Creason SA, Shibata S, Verlinde CLMJ, Hol WGJ, Buckner FS, Fan E. Huang W, et al. Among authors: buckner fs. Eur J Med Chem. 2016 Nov 29;124:1081-1092. doi: 10.1016/j.ejmech.2016.10.024. Epub 2016 Oct 14. Eur J Med Chem. 2016. PMID: 27788467 Free PMC article.

2

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase.

Buckner FS, Verlinde CL, La Flamme AC, Van Voorhis WC. Buckner FS, et al. Antimicrob Agents Chemother. 1996 Nov;40(11):2592-7. doi: 10.1128/AAC.40.11.2592. Antimicrob Agents Chemother. 1996. PMID: 8913471 Free PMC article.

3

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics.

Yokoyama K, Trobridge P, Buckner FS, Van Voorhis WC, Stuart KD, Gelb MH. Yokoyama K, et al. Among authors: buckner fs. J Biol Chem. 1998 Oct 9;273(41):26497-505. doi: 10.1074/jbc.273.41.26497. J Biol Chem. 1998. PMID: 9756885 Free article.

4

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.

Aronov AM, Suresh S, Buckner FS, Van Voorhis WC, Verlinde CL, Opperdoes FR, Hol WG, Gelb MH. Aronov AM, et al. Among authors: buckner fs. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4273-8. doi: 10.1073/pnas.96.8.4273. Proc Natl Acad Sci U S A. 1999. PMID: 10200252 Free PMC article.

5

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei.

Buckner FS, Yokoyama K, Nguyen L, Grewal A, Erdjument-Bromage H, Tempst P, Strickland CL, Xiao L, Van Voorhis WC, Gelb MH. Buckner FS, et al. J Biol Chem. 2000 Jul 21;275(29):21870-6. doi: 10.1074/jbc.M000975200. J Biol Chem. 2000. PMID: 10749864 Free PMC article.

6

Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.

Bressi JC, Choe J, Hough MT, Buckner FS, Van Voorhis WC, Verlinde CL, Hol WG, Gelb MH. Bressi JC, et al. Among authors: buckner fs. J Med Chem. 2000 Nov 2;43(22):4135-50. doi: 10.1021/jm000287a. J Med Chem. 2000. PMID: 11063610

7

Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.

Bressi JC, Verlinde CL, Aronov AM, Shaw ML, Shin SS, Nguyen LN, Suresh S, Buckner FS, Van Voorhis WC, Kuntz ID, Hol WG, Gelb MH. Bressi JC, et al. Among authors: buckner fs. J Med Chem. 2001 Jun 21;44(13):2080-93. doi: 10.1021/jm000472o. J Med Chem. 2001. PMID: 11405646 Free PMC article.

8

Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.

Clerici F, Gelmi ML, Yokoyama K, Pocar D, Van Voorhis WC, Buckner FS, Gelb MH. Clerici F, et al. Among authors: buckner fs. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2217-20. doi: 10.1016/s0960-894x(02)00338-4. Bioorg Med Chem Lett. 2002. PMID: 12127541

9

Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase.

Buckner FS, Joubert BM, Boyle SM, Eastman RT, Verlinde CL, Matsuda SP. Buckner FS, et al. Mol Biochem Parasitol. 2003 Dec;132(2):75-81. doi: 10.1016/j.molbiopara.2003.07.004. Mol Biochem Parasitol. 2003. PMID: 14599667

10

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

Buckner F, Yokoyama K, Lockman J, Aikenhead K, Ohkanda J, Sadilek M, Sebti S, Van Voorhis W, Hamilton A, Gelb MH. Buckner F, et al. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15149-53. doi: 10.1073/pnas.2535442100. Epub 2003 Dec 1. Proc Natl Acad Sci U S A. 2003. PMID: 14657358 Free PMC article.

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