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Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected].
Manresa MC, Tambuwala MM, Radhakrishnan P, Harnoss JM, Brown E, Cavadas MA, Keogh CE, Cheong A, Barrett KE, Cummins EP, Schneider M, Taylor CT. Manresa MC, et al. Among authors: harnoss jm. Am J Physiol Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1076-G1090. doi: 10.1152/ajpgi.00229.2016. Epub 2016 Oct 27. Am J Physiol Gastrointest Liver Physiol. 2016. PMID: 27789456 Free article.
Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.
Radhakrishnan P, Ruh N, Harnoss JM, Kiss J, Mollenhauer M, Scherr AL, Platzer LK, Schmidt T, Podar K, Opferman JT, Weitz J, Schulze-Bergkamen H, Koehler BC, Ulrich A, Schneider M. Radhakrishnan P, et al. Among authors: harnoss jm. Cancer Res. 2016 Apr 15;76(8):2219-30. doi: 10.1158/0008-5472.CAN-15-1474. Epub 2016 Feb 26. Cancer Res. 2016. PMID: 26921340
Pharmacological HIF-inhibition attenuates postoperative adhesion formation.
Strowitzki MJ, Ritter AS, Radhakrishnan P, Harnoss JM, Opitz VM, Biller M, Wehrmann J, Keppler U, Scheer J, Wallwiener M, Schmidt T, Ulrich A, Schneider M. Strowitzki MJ, et al. Among authors: harnoss jm. Sci Rep. 2017 Oct 13;7(1):13151. doi: 10.1038/s41598-017-13638-z. Sci Rep. 2017. PMID: 29030625 Free PMC article.
Prolyl Hydroxylase Inhibition Mitigates Pouchitis.
Harnoss JM, Gebhardt JM, Radhakrishnan P, Leowardi C, Burmeister J, Halligan DN, Yuan S, Kennel KB, Strowitzki MJ, Schaible A, Lasitschka F, Taylor CT, Schneider M. Harnoss JM, et al. Inflamm Bowel Dis. 2020 Jan 6;26(2):192-205. doi: 10.1093/ibd/izz218. Inflamm Bowel Dis. 2020. PMID: 31618435 Review.
Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses.
Strowitzki MJ, Kimmer G, Wehrmann J, Ritter AS, Radhakrishnan P, Opitz VM, Tuffs C, Biller M, Kugler J, Keppler U, Harnoss JM, Klose J, Schmidt T, Blanco A, Taylor CT, Schneider M. Strowitzki MJ, et al. Among authors: harnoss jm. JCI Insight. 2021 Mar 30;6(8):e139191. doi: 10.1172/jci.insight.139191. JCI Insight. 2021. PMID: 33784253 Free PMC article.
Effect of Metformin on HIF-1α Signaling and Postoperative Adhesion Formation.
Biller ML, Tuffs C, Bleul M, Tran DT, Dupovac M, Keppler U, Harnoss JM, Probst P, Schneider M, Strowitzki MJ. Biller ML, et al. Among authors: harnoss jm. J Am Coll Surg. 2022 Jun 1;234(6):1167-1180. doi: 10.1097/XCS.0000000000000205. Epub 2022 Apr 8. J Am Coll Surg. 2022. PMID: 35703816
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