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PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.
Katsouri L, Lim YM, Blondrath K, Eleftheriadou I, Lombardero L, Birch AM, Mirzaei N, Irvine EE, Mazarakis ND, Sastre M. Katsouri L, et al. Among authors: mirzaei n. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12292-12297. doi: 10.1073/pnas.1606171113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791018 Free PMC article.
Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.
Parr C, Mirzaei N, Christian M, Sastre M. Parr C, et al. Among authors: mirzaei n. FASEB J. 2015 Feb;29(2):623-35. doi: 10.1096/fj.14-253211. Epub 2014 Nov 10. FASEB J. 2015. PMID: 25384422
In conclusion, Wnt/beta-catenin stimulation may repress BACE1 transcription via binding of TCF4 to BACE1 gene, and therefore, activation of the Wnt pathway may hold the key to new treatments of Alzheimer disease.-Parr, C., Mirzaei, N., Christian, M., and Sastre, M. …
In conclusion, Wnt/beta-catenin stimulation may repress BACE1 transcription via binding of TCF4 to BACE1 gene, and therefore, activation of …
84 results