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PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model.
Katsouri L, Lim YM, Blondrath K, Eleftheriadou I, Lombardero L, Birch AM, Mirzaei N, Irvine EE, Mazarakis ND, Sastre M. Katsouri L, et al. Among authors: sastre m. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12292-12297. doi: 10.1073/pnas.1606171113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791018 Free PMC article.
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MT. Sastre M, et al. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):443-8. doi: 10.1073/pnas.0503839103. Epub 2006 Jan 3. Proc Natl Acad Sci U S A. 2006. PMID: 16407166 Free PMC article.
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
Torres M, Price SL, Fiol-Deroque MA, Marcilla-Etxenike A, Ahyayauch H, Barceló-Coblijn G, Terés S, Katsouri L, Ordinas M, López DJ, Ibarguren M, Goñi FM, Busquets X, Vitorica J, Sastre M, Escribá PV. Torres M, et al. Among authors: sastre m. Biochim Biophys Acta. 2014 Jun;1838(6):1680-92. doi: 10.1016/j.bbamem.2013.12.016. Epub 2013 Dec 27. Biochim Biophys Acta. 2014. PMID: 24374316 Free article.
Activation of the Wnt/β-catenin pathway represses the transcription of the β-amyloid precursor protein cleaving enzyme (BACE1) via binding of T-cell factor-4 to BACE1 promoter.
Parr C, Mirzaei N, Christian M, Sastre M. Parr C, et al. Among authors: sastre m. FASEB J. 2015 Feb;29(2):623-35. doi: 10.1096/fj.14-253211. Epub 2014 Nov 10. FASEB J. 2015. PMID: 25384422
In conclusion, Wnt/beta-catenin stimulation may repress BACE1 transcription via binding of TCF4 to BACE1 gene, and therefore, activation of the Wnt pathway may hold the key to new treatments of Alzheimer disease.-Parr, C., Mirzaei, N., Christian, M., and Sastre, …
In conclusion, Wnt/beta-catenin stimulation may repress BACE1 transcription via binding of TCF4 to BACE1 gene, and therefore, activation of …
172 results