Lehane AM - Search Results

1

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.

Hewitt SN, Dranow DM, Horst BG, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragaña B, Choi R, Rivas KL, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Fairlamb AH, Gray DW, Read KD, Lehane AM, Kirk K, Myler PJ, Wernimont A, Walpole C, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WC. Hewitt SN, et al. Among authors: lehane am. ACS Infect Dis. 2017 Jan 13;3(1):34-44. doi: 10.1021/acsinfecdis.6b00078. Epub 2016 Nov 16. ACS Infect Dis. 2017. PMID: 27798837 Free PMC article.

2

Choline uptake into the malaria parasite is energized by the membrane potential.

Lehane AM, Saliba KJ, Allen RJ, Kirk K. Lehane AM, et al. Biochem Biophys Res Commun. 2004 Jul 23;320(2):311-7. doi: 10.1016/j.bbrc.2004.05.164. Biochem Biophys Res Commun. 2004. PMID: 15219828

3

Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.

Lehane AM, Marchetti RV, Spry C, van Schalkwyk DA, Teng R, Kirk K, Saliba KJ. Lehane AM, et al. J Biol Chem. 2007 Aug 31;282(35):25395-405. doi: 10.1074/jbc.M704610200. Epub 2007 Jun 20. J Biol Chem. 2007. PMID: 17581817 Free article.

4

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites.

Lehane AM, Hayward R, Saliba KJ, Kirk K. Lehane AM, et al. J Cell Sci. 2008 May 15;121(Pt 10):1624-32. doi: 10.1242/jcs.016758. Epub 2008 Apr 29. J Cell Sci. 2008. PMID: 18445688

5

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.

Lehane AM, Kirk K. Lehane AM, et al. Antimicrob Agents Chemother. 2008 Dec;52(12):4374-80. doi: 10.1128/AAC.00666-08. Epub 2008 Oct 13. Antimicrob Agents Chemother. 2008. PMID: 18852275 Free PMC article.

6

A polymorphic drug pump in the malaria parasite.

Saliba KJ, Lehane AM, Kirk K. Saliba KJ, et al. Among authors: lehane am. Mol Microbiol. 2008 Nov;70(4):775-9. doi: 10.1111/j.1365-2958.2008.06451.x. Mol Microbiol. 2008. PMID: 18990178 Free article.

7

An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum.

Henry RI, Cobbold SA, Allen RJ, Khan A, Hayward R, Lehane AM, Bray PG, Howitt SM, Biagini GA, Saliba KJ, Kirk K. Henry RI, et al. Among authors: lehane am. J Biol Chem. 2010 Jun 11;285(24):18615-26. doi: 10.1074/jbc.M110.120980. Epub 2010 Mar 23. J Biol Chem. 2010. PMID: 20332090 Free PMC article.

8

Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.

Lehane AM, Kirk K. Lehane AM, et al. Mol Microbiol. 2010 Aug;77(4):1039-51. doi: 10.1111/j.1365-2958.2010.07272.x. Epub 2010 Jun 28. Mol Microbiol. 2010. PMID: 20598081 Free article.

9

Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.

Lehane AM, van Schalkwyk DA, Valderramos SG, Fidock DA, Kirk K. Lehane AM, et al. Antimicrob Agents Chemother. 2011 May;55(5):2310-8. doi: 10.1128/AAC.01167-10. Epub 2011 Feb 22. Antimicrob Agents Chemother. 2011. PMID: 21343459 Free PMC article.

10

Membrane transport in the malaria parasite and its host erythrocyte.

Kirk K, Lehane AM. Kirk K, et al. Among authors: lehane am. Biochem J. 2014 Jan 1;457(1):1-18. doi: 10.1042/BJ20131007. Biochem J. 2014. PMID: 24325549 Review.

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