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The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.
Srinivasan S, Mir F, Huang JS, Khasawneh FT, Lam SC, Le Breton GC. Srinivasan S, et al. Among authors: le breton gc. J Biol Chem. 2009 Jun 12;284(24):16108-16117. doi: 10.1074/jbc.M809780200. Epub 2009 Apr 3. J Biol Chem. 2009. PMID: 19346255 Free PMC article.
Cell signalling through thromboxane A2 receptors.
Huang JS, Ramamurthy SK, Lin X, Le Breton GC. Huang JS, et al. Among authors: le breton gc. Cell Signal. 2004 May;16(5):521-33. doi: 10.1016/j.cellsig.2003.10.008. Cell Signal. 2004. PMID: 14751539 Review.
Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets.
Khasawneh FT, Huang JS, Mir F, Srinivasan S, Tiruppathi C, Le Breton GC. Khasawneh FT, et al. Among authors: le breton gc. Biochem Pharmacol. 2008 Jun 15;75(12):2301-15. doi: 10.1016/j.bcp.2008.03.014. Epub 2008 Mar 30. Biochem Pharmacol. 2008. PMID: 18455148 Free PMC article.
90 results