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Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.
Varshney A, Scott LJ, Welch RP, Erdos MR, Chines PS, Narisu N, Albanus RD, Orchard P, Wolford BN, Kursawe R, Vadlamudi S, Cannon ME, Didion JP, Hensley J, Kirilusha A; NISC Comparative Sequencing Program; Bonnycastle LL, Taylor DL, Watanabe R, Mohlke KL, Boehnke M, Collins FS, Parker SC, Stitzel ML. Varshney A, et al. Among authors: stitzel ml. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2301-2306. doi: 10.1073/pnas.1621192114. Epub 2017 Feb 13. Proc Natl Acad Sci U S A. 2017. PMID: 28193859 Free PMC article.
Genomics of Islet (Dys)function and Type 2 Diabetes.
Lawlor N, Khetan S, Ucar D, Stitzel ML. Lawlor N, et al. Among authors: stitzel ml. Trends Genet. 2017 Apr;33(4):244-255. doi: 10.1016/j.tig.2017.01.010. Epub 2017 Feb 27. Trends Genet. 2017. PMID: 28245910 Free PMC article. Review.
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus.
Roman TS, Cannon ME, Vadlamudi S, Buchkovich ML, Wolford BN, Welch RP, Morken MA, Kwon GJ, Varshney A, Kursawe R, Wu Y, Jackson AU; National Institutes of Health Intramural Sequencing Center (NISC) Comparative Sequencing Program; Erdos MR, Kuusisto J, Laakso M, Scott LJ, Boehnke M, Collins FS, Parker SCJ, Stitzel ML, Mohlke KL. Roman TS, et al. Among authors: stitzel ml. Diabetes. 2017 Sep;66(9):2521-2530. doi: 10.2337/db17-0464. Epub 2017 Jul 6. Diabetes. 2017. PMID: 28684635 Free PMC article.
The chromatin accessibility signature of human immune aging stems from CD8+ T cells.
Ucar D, Márquez EJ, Chung CH, Marches R, Rossi RJ, Uyar A, Wu TC, George J, Stitzel ML, Palucka AK, Kuchel GA, Banchereau J. Ucar D, et al. Among authors: stitzel ml. J Exp Med. 2017 Oct 2;214(10):3123-3144. doi: 10.1084/jem.20170416. Epub 2017 Sep 13. J Exp Med. 2017. PMID: 28904110 Free PMC article.
A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.
Kycia I, Wolford BN, Huyghe JR, Fuchsberger C, Vadlamudi S, Kursawe R, Welch RP, Albanus RD, Uyar A, Khetan S, Lawlor N, Bolisetty M, Mathur A, Kuusisto J, Laakso M, Ucar D, Mohlke KL, Boehnke M, Collins FS, Parker SCJ, Stitzel ML. Kycia I, et al. Among authors: stitzel ml. Am J Hum Genet. 2018 Apr 5;102(4):620-635. doi: 10.1016/j.ajhg.2018.02.020. Am J Hum Genet. 2018. PMID: 29625024 Free PMC article.
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