Lonial S - Search Results

1

Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.

Fan J, Lin R, Xia S, Chen D, Elf SE, Liu S, Pan Y, Xu H, Qian Z, Wang M, Shan C, Zhou L, Lei QY, Li Y, Mao H, Lee BH, Sudderth J, DeBerardinis RJ, Zhang G, Owonikoko T, Gaddh M, Arellano ML, Khoury HJ, Khuri FR, Kang S, Doetsch PW, Lonial S, Boggon TJ, Curran WJ, Chen J. Fan J, et al. Among authors: lonial s. Mol Cell. 2016 Dec 1;64(5):859-874. doi: 10.1016/j.molcel.2016.10.014. Epub 2016 Nov 17. Mol Cell. 2016. PMID: 27867011 Free PMC article.

2

The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT.

David E, Sun SY, Waller EK, Chen J, Khuri FR, Lonial S. David E, et al. Among authors: lonial s. Blood. 2005 Dec 15;106(13):4322-9. doi: 10.1182/blood-2005-06-2584. Epub 2005 Aug 23. Blood. 2005. PMID: 16118318 Free article.

3

Results of a clinical phase I dose-escalation study of cytarabine in combination with fixed-dose vinorelbine, paclitaxel, etoposide and cisplatin for the treatment of relapsed/refractory lymphoma.

Lonial S, Arellano M, Hutcherson D, Langston A, Flowers C, Heffner LT, Winton E, Jo Lechowicz M, Waller EK. Lonial S, et al. Leuk Lymphoma. 2006 Oct;47(10):2155-62. doi: 10.1080/10428190600774923. Leuk Lymphoma. 2006. PMID: 17071490 Clinical Trial.

4

14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells.

Dong S, Kang S, Gu TL, Kardar S, Fu H, Lonial S, Khoury HJ, Khuri F, Chen J. Dong S, et al. Among authors: lonial s. Blood. 2007 Jul 1;110(1):360-9. doi: 10.1182/blood-2006-12-065615. Epub 2007 Mar 27. Blood. 2007. PMID: 17389761 Free PMC article.

5

The farnesyltransferase inhibitor R115777 up-regulates the expression of death receptor 5 and enhances TRAIL-induced apoptosis in human lung cancer cells.

Qiu Y, Liu X, Zou W, Yue P, Lonial S, Khuri FR, Sun SY. Qiu Y, et al. Among authors: lonial s. Cancer Res. 2007 May 15;67(10):4973-80. doi: 10.1158/0008-5472.CAN-06-4044. Cancer Res. 2007. PMID: 17510428

6

The proteasome inhibitor PS-341 (bortezomib) up-regulates DR5 expression leading to induction of apoptosis and enhancement of TRAIL-induced apoptosis despite up-regulation of c-FLIP and survivin expression in human NSCLC cells.

Liu X, Yue P, Chen S, Hu L, Lonial S, Khuri FR, Sun SY. Liu X, et al. Among authors: lonial s. Cancer Res. 2007 May 15;67(10):4981-8. doi: 10.1158/0008-5472.CAN-06-4274. Cancer Res. 2007. PMID: 17510429

7

The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway.

Elrod HA, Lin YD, Yue P, Wang X, Lonial S, Khuri FR, Sun SY. Elrod HA, et al. Among authors: lonial s. Mol Cancer Ther. 2007 Jul;6(7):2029-38. doi: 10.1158/1535-7163.MCT-07-0004. Epub 2007 Jun 29. Mol Cancer Ther. 2007. PMID: 17604333

8

FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway.

Kang S, Dong S, Gu TL, Guo A, Cohen MS, Lonial S, Khoury HJ, Fabbro D, Gilliland DG, Bergsagel PL, Taunton J, Polakiewicz RD, Chen J. Kang S, et al. Among authors: lonial s. Cancer Cell. 2007 Sep;12(3):201-14. doi: 10.1016/j.ccr.2007.08.003. Cancer Cell. 2007. PMID: 17785202 Free PMC article.

9

Targeting 14-3-3 sensitizes native and mutant BCR-ABL to inhibition with U0126, rapamycin and Bcl-2 inhibitor GX15-070.

Dong S, Kang S, Lonial S, Khoury HJ, Viallet J, Chen J. Dong S, et al. Among authors: lonial s. Leukemia. 2008 Mar;22(3):572-7. doi: 10.1038/sj.leu.2405064. Epub 2007 Dec 13. Leukemia. 2008. PMID: 18079735 Free PMC article.

10

Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529.

Kang S, Dong S, Guo A, Ruan H, Lonial S, Khoury HJ, Gu TL, Chen J. Kang S, et al. Among authors: lonial s. J Biol Chem. 2008 Feb 22;283(8):4652-7. doi: 10.1074/jbc.M709673200. Epub 2007 Dec 21. J Biol Chem. 2008. PMID: 18156174 Free PMC article.

We recently reported that receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) directly tyrosine phosphorylates RSK2 at Tyr-529, which consequently regulates RSK2 activation by facilitating inactive ERK binding to RSK2 that is required for ERK-dependent phosphoryl …

We recently reported that receptor tyrosine kinase fibroblast growth factor receptor 3 (FGFR3) directly tyrosine phosphorylates RSK2 at Tyr- …

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