Botta M - Search Results

1

A Pyrazolo[3,4-d]pyrimidine Compound Reduces Cell Viability and Induces Apoptosis in Different Hematological Malignancies.

Laurenzana I, Caivano A, La Rocca F, Trino S, De Luca L, D'Alessio F, Schenone S, Falco G, Botta M, Del Vecchio L, Musto P. Laurenzana I, et al. Among authors: botta m. Front Pharmacol. 2016 Nov 7;7:416. doi: 10.3389/fphar.2016.00416. eCollection 2016. Front Pharmacol. 2016. PMID: 27872592 Free PMC article.

2

A Pyrazolo[3,4-d]pyrimidine compound inhibits Fyn phosphorylation and induces apoptosis in natural killer cell leukemia.

Laurenzana I, Caivano A, Trino S, De Luca L, La Rocca F, Simeon V, Tintori C, D'Alessio F, Teramo A, Zambello R, Traficante A, Maietti M, Semenzato G, Schenone S, Botta M, Musto P, Del Vecchio L. Laurenzana I, et al. Among authors: botta m. Oncotarget. 2016 Oct 4;7(40):65171-65184. doi: 10.18632/oncotarget.11496. Oncotarget. 2016. PMID: 27566560 Free PMC article.

3

Hit Recycling: Discovery of a Potent Carbonic Anhydrase Inhibitor by in Silico Target Fishing.

Mori M, Cau Y, Vignaroli G, Laurenzana I, Caivano A, Vullo D, Supuran CT, Botta M. Mori M, et al. Among authors: botta m. ACS Chem Biol. 2015 Sep 18;10(9):1964-9. doi: 10.1021/acschembio.5b00337. Epub 2015 Jul 1. ACS Chem Biol. 2015. PMID: 26121309

4

Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition.

Cozzi M, Giorgi F, Marcelli E, Pentimalli F, Forte IM, Schenone S, D'Urso V, De Falco G, Botta M, Giordano A, Indovina P. Cozzi M, et al. Among authors: botta m. Cell Cycle. 2012 Mar 1;11(5):1029-39. doi: 10.4161/cc.11.5.19519. Epub 2012 Mar 1. Cell Cycle. 2012. PMID: 22333592

5

Allosteric inhibitors of Bcr-Abl: towards novel myristate-pocket binders.

Radi M, Schenone S, Botta M. Radi M, et al. Among authors: botta m. Curr Pharm Biotechnol. 2013;14(5):477-87. doi: 10.2174/138920101405131111103750. Curr Pharm Biotechnol. 2013. PMID: 22429131 Review.

6

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents.

Tintori C, Laurenzana I, La Rocca F, Falchi F, Carraro F, Ruiz A, Esté JA, Kissova M, Crespan E, Maga G, Biava M, Brullo C, Schenone S, Botta M. Tintori C, et al. Among authors: botta m. ChemMedChem. 2013 Aug;8(8):1353-60. doi: 10.1002/cmdc.201300204. Epub 2013 Jun 28. ChemMedChem. 2013. PMID: 23813855

7

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors.

Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M. Tintori C, et al. Among authors: botta m, botta l. J Med Chem. 2015 Jun 11;58(11):4590-609. doi: 10.1021/acs.jmedchem.5b00140. Epub 2015 May 20. J Med Chem. 2015. PMID: 25923950

8

Novel dual Src/Abl inhibitors for hematologic and solid malignancies.

Schenone S, Brullo C, Musumeci F, Botta M. Schenone S, et al. Among authors: botta m. Expert Opin Investig Drugs. 2010 Aug;19(8):931-45. doi: 10.1517/13543784.2010.499898. Expert Opin Investig Drugs. 2010. PMID: 20557276 Review.

9

SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase-Mediated Cytotoxicity and Reduces Cell Migration.

Indovina P, Casini N, Forte IM, Garofano T, Cesari D, Iannuzzi CA, Del Porro L, Pentimalli F, Napoliello L, Boffo S, Schenone S, Botta M, Giordano A. Indovina P, et al. Among authors: botta m. J Cell Physiol. 2017 Jan;232(1):129-35. doi: 10.1002/jcp.25397. Epub 2016 Apr 19. J Cell Physiol. 2017. PMID: 27037775

10

Exploring the chemical space around the privileged pyrazolo[3,4-d]pyrimidine scaffold: toward novel allosteric inhibitors of T315I-mutated Abl.

Vignaroli G, Mencarelli M, Sementa D, Crespan E, Kissova M, Maga G, Schenone S, Radi M, Botta M. Vignaroli G, et al. Among authors: botta m. ACS Comb Sci. 2014 Apr 14;16(4):168-75. doi: 10.1021/co500004e. Epub 2014 Mar 18. ACS Comb Sci. 2014. PMID: 24597676

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