Temesi DG - Search Results

1

Methanol adducts leading to the identification of a reactive aldehyde metabolite of CPAQOP in human liver microsomes by ultra-high-performance liquid chromatography/mass spectrometry.

Martin S, Lenz EM, Smith R, Temesi DG, Orton AL, Clench MR. Martin S, et al. Among authors: temesi dg. Rapid Commun Mass Spectrom. 2017 Jan 15;31(1):145-151. doi: 10.1002/rcm.7772. Rapid Commun Mass Spectrom. 2017. PMID: 27943491

2

High-throughput metabolic stability studies in drug discovery by orthogonal acceleration time-of-flight (OATOF) with analogue-to-digital signal capture (ADC).

Temesi DG, Martin S, Smith R, Jones C, Middleton B. Temesi DG, et al. Rapid Commun Mass Spectrom. 2010 Jun 30;24(12):1730-6. doi: 10.1002/rcm.4546. Rapid Commun Mass Spectrom. 2010. PMID: 20499316

3

The metabolism of [14C]-zibotentan (ZD4054) in rat, dog and human, the loss of the radiolabel and the identification of an anomalous peak, derived from the animal feed.

Lenz EM, Kenyon A, Martin S, Temesi D, Clarkson-Jones J, Tomkinson H. Lenz EM, et al. J Pharm Biomed Anal. 2011 Jun 1;55(3):500-17. doi: 10.1016/j.jpba.2011.02.005. Epub 2011 Mar 12. J Pharm Biomed Anal. 2011. PMID: 21398067

4

Reaction of homopiperazine with endogenous formaldehyde: a carbon hydrogen addition metabolite/product identified in rat urine and blood.

Martin S, Lenz EM, Temesi D, Wild M, Clench MR. Martin S, et al. Drug Metab Dispos. 2012 Aug;40(8):1478-86. doi: 10.1124/dmd.112.044917. Epub 2012 May 1. Drug Metab Dispos. 2012. PMID: 22550270

5

Factors to consider in the development of generic bioanalytical high-performance liquid chromatographic-mass spectrometric methods to support drug discovery.

Law B, Temesi D. Law B, et al. J Chromatogr B Biomed Sci Appl. 2000 Oct 1;748(1):21-30. doi: 10.1016/s0378-4347(00)00319-4. J Chromatogr B Biomed Sci Appl. 2000. PMID: 11092583

6

Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.

Foster AJ, Prime LH, Gustafsson F, Temesi DG, Isin EM, Midlöv J, Castagnoli N Jr, Kenna JG. Foster AJ, et al. Among authors: temesi dg. Chem Res Toxicol. 2013 Jan 18;26(1):124-35. doi: 10.1021/tx300418w. Epub 2012 Dec 12. Chem Res Toxicol. 2013. PMID: 23234359

7

The stability of amitriptyline N-oxide and clozapine N-oxide on treated and untreated dry blood spot cards.

Temesi D, Swales J, Keene W, Dick S. Temesi D, et al. J Pharm Biomed Anal. 2013 Mar 25;76:164-8. doi: 10.1016/j.jpba.2012.11.044. Epub 2012 Dec 16. J Pharm Biomed Anal. 2013. PMID: 23333684

8

Determination of paracetamol in mouse, rat and dog plasma samples by laser diode thermal desorption--APCI-MS/MS.

Swales JG, Temesi DG, Denn M, Murphy K. Swales JG, et al. Among authors: temesi dg. Bioanalysis. 2012 Jun;4(11):1327-35. doi: 10.4155/bio.12.68. Bioanalysis. 2012. PMID: 22720651

9

Biophysical methods in drug discovery from small molecule to pharmaceutical.

Holdgate G, Geschwindner S, Breeze A, Davies G, Colclough N, Temesi D, Ward L. Holdgate G, et al. Methods Mol Biol. 2013;1008:327-55. doi: 10.1007/978-1-62703-398-5_12. Methods Mol Biol. 2013. PMID: 23729258

10

Synthesis and evaluation of PEG414, a novel formulating agent that avoids analytical problems associated with polydisperse vehicles such as PEG400.

Temesi D, Law B, Howe N. Temesi D, et al. J Pharm Sci. 2003 Dec;92(12):2512-8. doi: 10.1002/jps.10514. J Pharm Sci. 2003. PMID: 14603497

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